Recombinant Salmonella-based 4-1BBL vaccine enhances T cell immunity and inhibits the development of colorectal cancer in rats: in vivo effects of vaccine containing 4-1BBL.
Recombinant Salmonella-based 4-1BBL vaccine enhances T cell immunity and inhibits the development of colorectal cancer in rats: in vivo effects of vaccine containing 4-1BBL.
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基于重组沙门氏菌的 4-1BBL 疫苗增强 T 细胞免疫并抑制大鼠结直肠癌的发展：含有 4-1BBL 的疫苗的体内效果
DOI：
10.1186/1423-0127-20-8
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发表时间：
2013-02-17
影响因子：
11
通讯作者：
Chen W
中科院分区：
文献类型：
--
作者：
Ye J;Li L;Zhang Y;Zhang X;Ren D;Chen W
研究背景疫苗免疫疗法在肿瘤治疗中具有很大的吸引力。本研究旨在探讨重组沙门氏菌（SL 3261）4-1BB配体（4-1BBL）疫苗对大鼠大肠癌发生的影响及其可能的免疫机制。在SL 3261和SL 3261 C组大鼠中检测到相当数量的肿瘤。相比之下，肿瘤数量显著减少，脾脏和结直肠组织中4-1BBL表达水平升高，外周血和脾脏CD 3 + CD 25 +T细胞频率升高，SL 3261 R组大鼠脾T细胞IFN-γ反应增强。结论我们的结果表明，用携带4- 1BBL基因能有效增强T细胞免疫功能，抑制致癌物诱导的大鼠大肠癌的发生。
BackgroundImmunotherapy with vaccines is attractive for the treatment of cancer. This study is aimed at determining the effect of recombinant Salmonella (SL3261)-based 4-1BB ligand (4-1BBL) vaccine on the development of colorectal cancers and the potential immune mechanisms in rats.ResultsIn comparison with that in the PBS group, similar levels of 4-1BBL expression, the frequency of T cells, IFN-γ responses, and comparable numbers of tumors were detected in the SL3261 and SL3261C groups of rats. In contrast, significantly fewer numbers of tumors, increased levels of 4-1BBL expression in the spleens and colorectal tissues, higher frequency of peripheral blood and splenic CD3+CD25+T cells, and stronger splenic T cell IFN-γ responses were detected in the SL3261R group of rats.ConclusionOur results indicated that vaccination with recombinant attenuated Salmonella harboring the 4-1BBL gene efficiently enhanced T cell immunity and inhibited the development of carcinogen-induced colorectal cancers in rats.
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影响因子：
6.4
作者：
Cheuk, ATC;Mufti, GJ;Guinn, BA
通讯作者：
Guinn, BA
影响因子：
5.5
作者：
Ye, Jian-xin;Zhang, Yuan-ting;Chen, Wei-chang
通讯作者：
Chen, Wei-chang
影响因子：
15.3
作者：
Shuford, WW;Klussman, K;Tritchler, DD;Loo, DT;Chalupny, J;Siadak, AW;Brown, TJ;Emswiler, J;Raecho, H;Larsen, CP;Pearson, TC;Ledbetter, JA;Aruffo, A;Mittler, RS
通讯作者：
Mittler, RS
影响因子：
11.2
作者：
Sharma RK;Schabowsky RH;Srivastava AK;Elpek KG;Madireddi S;Zhao H;Zhong Z;Miller RW;Macleod KJ;Yolcu ES;Shirwan H
通讯作者：
Shirwan H
影响因子：
9.6
作者：
Reyes, E;Prieto, AF;Alvarez-Mon, M
通讯作者：
Alvarez-Mon, M