Act Locally, Act Globally-Microbiota, Barriers, and Cytokines in Atherosclerosis.
Act Locally, Act Globally-Microbiota, Barriers, and Cytokines in Atherosclerosis.
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DOI：
10.3390/cells10020348
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发表时间：
2021-02-07
期刊：
影响因子：
6
通讯作者：
Koltsova EK
中科院分区：
文献类型：
--
作者：
Kurilenko N;Fatkhullina AR;Mazitova A;Koltsova EK
动脉粥样硬化是一种脂质驱动的慢性炎症性疾病，其特征是动脉壁中动脉粥样硬化斑块的形成和进行性生长。动脉粥样硬化是中风和心脏病发作的主要诱发因素。各种免疫介导的机制与疾病的发生和进展有关。细胞因子是先天性和适应性免疫细胞以及主动脉壁中的非造血细胞之间串扰的关键介质，并且是动脉粥样硬化调节中的新兴参与者。动脉粥样硬化的进展总是与局部和全身促炎细胞因子水平升高有关。细胞因子在动脉粥样硬化斑块中的作用已被广泛研究。然而，细胞因子信号传导的细胞特异性作用，特别是细胞因子在心血管疾病背景下调节与微生物群密切相关的屏障组织中的作用直到最近才被发现。在这里，我们总结了关于细胞因子在粘膜屏障中的功能以及细胞因子、屏障和微生物群之间相互作用的知识，并讨论了它们对动脉粥样硬化发展的已知和潜在影响。
Atherosclerosis is a lipid-driven chronic inflammatory disease that is characterized by the formation and progressive growth of atherosclerotic plaques in the wall of arteries. Atherosclerosis is a major predisposing factor for stroke and heart attack. Various immune-mediated mechanisms are implicated in the disease initiation and progression. Cytokines are key mediators of the crosstalk between innate and adaptive immune cells as well as non-hematopoietic cells in the aortic wall and are emerging players in the regulation of atherosclerosis. Progression of atherosclerosis is always associated with increased local and systemic levels of pro-inflammatory cytokines. The role of cytokines within atherosclerotic plaque has been extensively investigated; however, the cell-specific role of cytokine signaling, particularly the role of cytokines in the regulation of barrier tissues tightly associated with microbiota in the context of cardiovascular diseases has only recently come to light. Here, we summarize the knowledge about the function of cytokines at mucosal barriers and the interplay between cytokines, barriers, and microbiota and discuss their known and potential implications for atherosclerosis development.
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DOI：
10.1126/science.aam9949
发表时间：
2017-08-11
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Byndloss MX;Olsan EE;Rivera-Chávez F;Tiffany CR;Cevallos SA;Lokken KL;Torres TP;Byndloss AJ;Faber F;Gao Y;Litvak Y;Lopez CA;Xu G;Napoli E;Giulivi C;Tsolis RM;Revzin A;Lebrilla CB;Bäumler AJ
通讯作者：
Bäumler AJ
影响因子：
30.3
作者：
Araujo, Joao R.;Tazi, Asmaa;Sansonetti, Philippe J.
通讯作者：
Sansonetti, Philippe J.
影响因子：
5.3
作者：
Bhaskar, Vinay;Yin, Johnny;Kantak, Seema S.
通讯作者：
Kantak, Seema S.
影响因子：
10.8
作者：
Brauner, Susanna;Jiang, Xintong;Wahren-Herlenius, Marie
通讯作者：
Wahren-Herlenius, Marie
影响因子：
8.8
作者：
Castillo-dela Cruz, Patricia;Wanek, Alanna G.;Kolls, Jay K.
通讯作者：
Kolls, Jay K.