Accuracy of narrow band imaging for detecting the malignant transformation of oral potentially malignant disorders: A systematic review and meta-analysis.
Accuracy of narrow band imaging for detecting the malignant transformation of oral potentially malignant disorders: A systematic review and meta-analysis.
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窄带成像检测口腔潜在恶性疾病恶变的准确性：系统评价和荟萃分析
DOI：
10.3389/fsurg.2022.1068256
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发表时间：
2022
影响因子：
1.8
通讯作者：
Chen, Qianming
中科院分区：
文献类型：
--
作者：
Zhang, You;Wu, Yuqi;Pan, Dan;Zhang, Zhenyu;Jiang, Lu;Feng, Xiaodong;Jiang, Yuchen;Luo, Xiaobo;Chen, Qianming
关键词：
口腔潜在恶性疾病(OPMDs)是一组具有恶性转化潜能并发展为口腔鳞状细胞癌(OSCC)的疾病。窄带成像(NBI)已在临床上用于OPMD和OSCC的辅助诊断。本研究旨在应用上皮内乳头状毛细血管环(IPCL)分类方法，综合评价NBI对OPMD恶变的诊断准确性。选择NBI在OPMD/OSCC检测中诊断有效性的研究。检索4个数据库，11篇文献纳入荟萃分析。我们进行了四个亚组分析，将IPCL I/II定义为阴性诊断结果，将无/轻度异型增生定义为阴性病理结果。使用随机效应模型对汇集的数据进行分析。采用Meta回归分析探讨异质性。4个亚组合并分析后发现，以IPCLII及以上为临床阳性结果的亚组1对OPMDs恶变的总体诊断准确率最高，其敏感度和特异度分别为0.87(95%可信区间[0.67，0.96]，p <； 0.001)和0.83[95%CI(0.56，0.95)，p <； 0.001]；而其他3个亚组的敏感度和特异度相对较低。NBI是一种有前景的非侵入性辅助工具，可用于识别OPMDs的恶性转化。IPCL分级是目前NBI临床应用的可靠标准。在排除潜在的假阳性结果后，建议对这些IPCL II或以上的口腔病变进行活检，以便早期准确诊断和处理。
Oral potentially malignant disorders (OPMDs) are a spectrum of diseases that harbor the potential of malignant transformation and developing into oral squamous cell carcinoma (OSCC). Narrow band imaging (NBI) has been clinically utilized for the adjuvant diagnosis of OPMD and OSCC. This study aimed to comprehensively evaluate the diagnostic accuracy of NBI for malignant transformations of OPMD by applying the intraepithelial papillary capillary loop (IPCL) classification approach. Studies reporting the diagnostic validity of NBI in the detection of OPMD/OSCC were selected. Four databases were searched and 11 articles were included in the meta-analysis. We performed four subgroup analyses by defining IPCL I/II as negative diagnostic results and no/mild dysplasia as negative pathological outcome. Pooled data were analyzed using random-effects models. Meta-regression analysis was performed to explore heterogeneity. After pooled analysis of the four subgroups, we found that subgroup 1, defining IPCL II and above as a clinically positive result, demonstrated the most optimal overall diagnostic accuracy for the malignant transformation of OPMDs, with a sensitivity and specificity of NBI of 0.87 (95% confidence interval (CI) [0.67, 0.96], p < 0.001) and 0.83 [95% CI (0.56, 0.95), p < 0.001], respectively; while the other 3 subgroups displayed relatively low sensitivity or specificity. NBI is a promising and non-invasive adjunctive tool for identifying malignant transformations of OPMDs. The IPCL grading is currently a sound criterion for the clinical application of NBI. After excluding potentially false positive results, these oral lesions classified as IPCL II or above are suggested to undergo biopsy for early and accurate diagnosis as well as management.
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影响因子：
5.2
作者：
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影响因子：
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作者：
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Umapathy C
影响因子：
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作者：
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通讯作者：
Peretti, Giorgio
DOI：
10.3390/ijerph17249160
发表时间：
2020-12-08
影响因子：
--
作者：
Abati S;Bramati C;Bondi S;Lissoni A;Trimarchi M
通讯作者：
Trimarchi M