Aetiological considerations and risk factors for multi-infarct dementia.
Aetiological considerations and risk factors for multi-infarct dementia.
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多发性梗塞性痴呆的病因学考虑和危险因素。
DOI：
10.1136/jnnp.51.12.1489
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
K. Mortel
中科院分区：
文献类型：
--
作者：
J. S. Meyer;Karen McClintic;P. S. ROBERT L ROGERS;K. Mortel
对 175 名多发性梗塞性痴呆 (MID) 患者进行了中风危险因素以及脑血管病变类型的评估。中风相关危险因素的发生率如下：高血压（66%）、心脏病（47%）、吸烟（37%）、糖尿病（20%）、适量饮酒（19%）和高脂血症（21%）。最常见的病变类型是脑部多发性腔隙性梗塞（43%）。这些与其他类型的中风相结合，导致另外 21% 的中风。 18% 的患者单独发生颈动脉和椎基底动脉的动脉粥样硬化闭塞性疾病，另外 25% 的患者与其他类型的中风相关。栓塞性脑梗塞单独存在的比例为 8%，合并其他类型中风的比例为 15%。 MID 在男性中（62%）比女性更常见（p 小于 0.002）。平均双半球灰质脑血流量 (CBF) 值呈现波动过程，当汇总并比较不同类型 MID 的结果时，颅外闭塞性疾病和/或多发性腔隙性梗塞导致 CBF 值最低。与梗塞脑的总体积相比，脑梗塞的位置与认知障碍的相关性更为重要。随访 31 个月的 125 名 MID 患者的死亡率为 5%。三例尸检病例证实了脑血管病变类型的正确临床分类。
One hundred and seventy five multi-infarct dementia (MID) patients were evaluated for risk factors for stroke as well as for the types of cerebrovascular lesions that were present. The incidence of associated risk factors for stroke were as follows: hypertension (66%), heart disease (47%), cigarette smoking (37%), diabetes mellitus (20%), moderate alcohol consumption (19%) and hyperlipidaemia (21%). The most frequently occurring type of lesions were multiple lacunar infarctions of the brain (43%). These were combined with other types of stroke in an additional 21%. Atherosclerotic occlusive disease of the carotid and vertebrobasilar arteries occurred alone in 18% and was associated with other types of stroke in another 25%. Embolic cerebral infarctions were present alone in 8% and were combined with other types of stroke in 15%. MID was more frequent in men (62%) than women (p less than 0.002). Mean bihemispheric gray matter cerebral blood flow (CBF) values showed a fluctuating course and when results were pooled and compared between different types of MID, extracranial occlusive disease and/or multiple lacunar infarctions resulted in lowest CBF values. The location of cerebral infarctions was more importantly related to cognitive impairments than was the total volume of infarcted brain. Mortality rates among 125 MID patients followed for 31 months has been 5%. Correct clinical classification of the types of cerebrovascular lesions was confirmed in three necropsied cases.
影响因子：
5
作者：
FAZEKAS, F;CHAWLUK, JB;ZIMMERMAN, RA
通讯作者：
ZIMMERMAN, RA