Memorizing environmental signals through feedback and feedforward loops.

Memorizing environmental signals through feedback and feedforward loops.
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通过反馈和前馈循环来记住环境信号。

DOI:
10.1016/j.ceb.2020.11.008
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发表时间:
2021-04
影响因子:
7.5
通讯作者:
Hao N
Hao N
中科院分区:
生物学2区
文献类型:
--
作者:
Jiang Y;Hao N

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Cells in diverse organisms can store the information of previous environmental conditions for long periods of time. This form of cellular memory adjusts the cell’s responses to future challenges, providing fitness advantages in fluctuating environments. Many biological functions, including cellular memory, are mediated by specific recurring patterns of interactions among proteins and genes, known as “network motifs.” In this review, we focus on three well-characterized network motifs - negative feedback loops, positive feedback loops, and feedforward loops, which underlie different types of cellular memories. We describe the latest studies identifying these motifs in various molecular processes and discuss how the topologies and dynamics of these motifs can enable memory encoding and storage.
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