Joining the dots: from chromatin remodeling to neuronal plasticity.
Joining the dots: from chromatin remodeling to neuronal plasticity.
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DOI：
10.1016/j.conb.2010.04.005
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发表时间：
2010-08
影响因子：
5.7
通讯作者：
Sassone-Corsi, Paolo
中科院分区：
文献类型：
--
作者：
Zocchi, Loredana;Sassone-Corsi, Paolo
近年来，表观遗传学领域取得了惊人的进展。将表观遗传调控与大脑功能联系起来的多种证据不断积累。神经元每天将各种外部刺激转化为基因表达的快速或持久的变化。控制是通过 DNA 和染色质上发生的几种翻译后修饰来实现的。特定的修饰介导许多发育过程和成人大脑功能，例如突触可塑性和记忆。在这篇综述中，我们重点关注介导持久神经元反应的关键染色质重塑事件。具有挑战性的目标是充分了解大脑中的这些表观遗传途径，以便它们可能有助于未来特定药理学策略的开发。
In recent years spectacular advances in the field of epigenetics have taken place. Multiple lines of evidence that connect epigenetic regulation to brain functions have been accumulating. Neurons daily convert a variety of external stimuli into rapid or long-lasting changes in gene expression. Control is achieved through several post-translational modifications that occur both on DNA and chromatin. Specific modifications mediate many developmental processes and adult brain functions, such as synaptic plasticity and memory. In this review, we focus on critical chromatin remodeling events that mediate long-lasting neuronal responses. The challenging goal is to reach sufficient understanding of these epigenetic pathways in the brain so that they may be useful for future development of specific pharmacological strategies.
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影响因子：
3.5
作者：
Ben-Shachar S;Chahrour M;Thaller C;Shaw CA;Zoghbi HY
通讯作者：
Zoghbi HY
DOI：
10.1073/pnas.95.21.12202
发表时间：
1998-10-13
影响因子：
11.1
作者：
De Cesare, D;Jacquot, S;Sassone-Corsi, P
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Sassone-Corsi, P
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作者：
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通讯作者：
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影响因子：
2
作者：
Chwang, Wilson B.;O'Riordan, Kenneth J.;Sweatt, J. David
通讯作者：
Sweatt, J. David