Divergent trajectories of antiviral memory after SARS-CoV-2 infection.
Divergent trajectories of antiviral memory after SARS-CoV-2 infection.
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DOI：
10.1038/s41467-022-28898-1
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发表时间：
2022-03-10
影响因子：
16.6
通讯作者：
Dunachie SJ
中科院分区：
文献类型：
--
作者：
Tomic A;Skelly DT;Ogbe A;O'Connor D;Pace M;Adland E;Alexander F;Ali M;Allott K;Azim Ansari M;Belij-Rammerstorfer S;Bibi S;Blackwell L;Brown A;Brown H;Cavell B;Clutterbuck EA;de Silva T;Eyre D;Lumley S;Flaxman A;Grist J;Hackstein CP;Halkerston R;Harding AC;Hill J;James T;Jay C;Johnson SA;Kronsteiner B;Lie Y;Linder A;Longet S;Marinou S;Matthews PC;Mellors J;Petropoulos C;Rongkard P;Sedik C;Silva-Reyes L;Smith H;Stockdale L;Taylor S;Thomas S;Tipoe T;Turtle L;Vieira VA;Wrin T;OPTIC Clinical Group;PITCH Study Group;C-MORE Group;Pollard AJ;Lambe T;Conlon CP;Jeffery K;Travis S;Goulder P;Frater J;Mentzer AJ;Stafford L;Carroll MW;James WS;Klenerman P;Barnes E;Dold C;Dunachie SJ
对严重急性呼吸综合征冠状病毒2感染的获得性免疫的轨迹尚未完全了解。我们对接种疫苗前的英国医护人员进行了一项详细的纵向队列研究，研究对象为2020年4月至6月的无症状或有症状感染者。在这里，我们显示了一个高度可变的反应范围，其中一些（T细胞干扰素-γ ELISpot，N-特异性抗体）随着时间的推移而减弱，而其他（尖峰特异性抗体，B细胞记忆ELISpot）是稳定的。我们使用综合分析和机器学习方法（SIMON -顺序迭代建模过夜）来探索这种异质性。我们确定了一个具有较高抗体应答和干扰素-γ ELISpot T细胞应答的参与者亚组，长期免疫的稳健轨迹与针对感染（维多利亚）菌株以及针对变体B.1.1.7（α）和B.1.351（β）的较高水平的中和抗体相关。这些可变的轨迹后，早期启动可能会定义随后的保护，从严重的疾病，从新的变种。免疫记忆的参与是保护性抗SARS-CoV-2 B和T细胞应答的关键组成部分。在这里，作者评估了一组英国医护人员的B和T细胞对感染的反应，并纵向追踪了早期引发后显示不同轨迹的隔室。
The trajectories of acquired immunity to severe acute respiratory syndrome coronavirus 2 infection are not fully understood. We present a detailed longitudinal cohort study of UK healthcare workers prior to vaccination, presenting April-June 2020 with asymptomatic or symptomatic infection. Here we show a highly variable range of responses, some of which (T cell interferon-gamma ELISpot, N-specific antibody) wane over time, while others (spike-specific antibody, B cell memory ELISpot) are stable. We use integrative analysis and a machine-learning approach (SIMON - Sequential Iterative Modeling OverNight) to explore this heterogeneity. We identify a subgroup of participants with higher antibody responses and interferon-gamma ELISpot T cell responses, and a robust trajectory for longer term immunity associates with higher levels of neutralising antibodies against the infecting (Victoria) strain and also against variants B.1.1.7 (alpha) and B.1.351 (beta). These variable trajectories following early priming may define subsequent protection from severe disease from novel variants. The engagement of immunological memory is a key component to the protective anti-SARS-CoV-2 B and T cell responses. Here the authors assess the B and T cells of a cohort of UK healthcare workers in response to infection and longitudinally track the compartment showing distinct trajectories following early priming.
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DOI：
10.1093/infdis/jiaa784
发表时间：
2021-03-29
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Klingler J;Weiss S;Itri V;Liu X;Oguntuyo KY;Stevens C;Ikegame S;Hung CT;Enyindah-Asonye G;Amanat F;Baine I;Arinsburg S;Bandres JC;Kojic EM;Stoever J;Jurczyszak D;Bermudez-Gonzalez M;Nádas A;Liu S;Lee B;Zolla-Pazner S;Hioe CE
通讯作者：
Hioe CE
SARS-COV-2血统的估计可传播和影响B.1.1.7在英国。
DOI：
10.1126/science.abg3055
发表时间：
2021-04-09
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Davies NG;Abbott S;Barnard RC;Jarvis CI;Kucharski AJ;Munday JD;Pearson CAB;Russell TW;Tully DC;Washburne AD;Wenseleers T;Gimma A;Waites W;Wong KLM;van Zandvoort K;Silverman JD;CMMID COVID-19 Working Group;COVID-19 Genomics UK (COG-UK) Consortium;Diaz-Ordaz K;Keogh R;Eggo RM;Funk S;Jit M;Atkins KE;Edmunds WJ
通讯作者：
Edmunds WJ
影响因子：
3.2
作者：
Abdi, Herve;Williams, Lynne J.
通讯作者：
Williams, Lynne J.
影响因子：
11.8
作者：
Fan, Vincent S.;Dominitz, Jason A.;Ioannou, George N.
通讯作者：
Ioannou, George N.
DOI：
10.1093/infdis/jiy098
发表时间：
2018-05-05
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Kiyuka PK;Agoti CN;Munywoki PK;Njeru R;Bett A;Otieno JR;Otieno GP;Kamau E;Clark TG;van der Hoek L;Kellam P;Nokes DJ;Cotten M
通讯作者：
Cotten M