Retinal photodamage mediated by all-trans-retinal.
Retinal photodamage mediated by all-trans-retinal.
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DOI：
10.1111/j.1751-1097.2012.01143.x
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发表时间：
2012-11
影响因子：
3.3
通讯作者：
Maeda A
中科院分区：
文献类型：
--
作者：
Maeda T;Golczak M;Maeda A
全反式视网膜(ALL)活性维生素A醛的积聚是引发视网膜光损伤的关键因素之一。这种光损伤的特征是由急性和慢性光暴露引起的视网膜细胞进行性死亡。光激活的视紫红质释放全反式视紫红质，随后被三磷酸腺苷结合盒转运体4转运，并被光感受器细胞中的全反式视黄醇脱氢酶还原为全反式视黄醇。在光感受器中清除全反式醛的任何干扰都会导致这种反应性醛及其有毒缩合产物的积累。这种积聚可能导致视网膜营养不良的表现，包括人类视网膜退行性疾病，如Stargardt病和年龄相关性黄斑变性。在这里，我们讨论了光感受器细胞通过连续的酶反应清除的机制，视觉(类视黄醇)循环，以及视网膜光损伤的潜在分子途径。我们还回顾了监测视网膜健康状态的最新成像技术以及预防全经视网膜光损伤的新治疗策略。
Accumulation of all-trans-retinal (all-trans-RAL), reactive vitamin A aldehyde, is one of the key factors in initiating retinal photodamage. This photodamage is characterized by progressive retinal cell death evoked by light exposure in both an acute and chronic fashion. Photo-activated rhodopsin releases all-trans-RAL which is subsequently transported by ATP–binding cassette transporter 4 and reduced to all-trans-retinol by all-trans-retinol dehydrogenases located in photoreceptor cells. Any interruptions in the clearing of all-trans-RAL in the photoreceptors can cause an accumulation of this reactive aldehyde and its toxic condensation products. This accumulation may result in the manifestation of retinal dystrophy including human retinal degenerative diseases such as Stargardt’s disease and age-related macular degeneration. Here, we discuss the mechanisms of all-trans-RAL clearance in photoreceptor cells by sequential enzymatic reactions, the visual (retinoid) cycle, and potential molecular pathways of retinal photodamage. We also review recent imaging technologies to monitor retinal health status as well as novel therapeutic strategies preventing all-trans-RAL-associated retinal photodamage.
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影响因子：
4.4
作者：
Burke, Tomas R.;Rhee, David W.;Greenstein, Vivienne C.
通讯作者：
Greenstein, Vivienne C.
影响因子：
4.8
作者：
Chen, Yu;Okano, Kiichiro;Palczewski, Krzysztof
通讯作者：
Palczewski, Krzysztof
影响因子：
56.9
作者：
Allikmets, R;Shroyer, NF;Leppert, M
通讯作者：
Leppert, M
DOI：
10.1073/pnas.93.2.560
发表时间：
1996-01-23
影响因子：
11.1
作者：
Baylor, D
通讯作者：
Baylor, D
Stargardt疾病患者的眼底自动荧光和视网膜结构的比较。
影响因子：
4.4
作者：
Gomes NL;Greenstein VC;Carlson JN;Tsang SH;Smith RT;Carr RE;Hood DC;Chang S
通讯作者：
Chang S