Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex.
Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex.
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DOI：
10.1111/j.1349-7006.2001.tb01135.x
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发表时间：
2001-06
期刊：
影响因子：
--
通讯作者：
Yamamoto T
中科院分区：
文献类型：
--
作者：
Yoshida Y;Hosoda E;Nakamura T;Yamamoto T
ANA是一种35 kDa的蛋白质，属于一个新兴的抗增殖蛋白家族，由Tob、Tob 2、ANA/BTG 3、PC 3B、PC 3/TIS 21/BTG 2和BTG 1组成。除ANA和PC 3B外，所有这些都显示与CCR 4转录因子相关蛋白Cafl相互作用。在这里，我们表明，ANA也与Cafl，ANA是首选的合作伙伴之间的Tob家族蛋白的Cafl。虽然ANA可能在其氨基末端hal与Cafl相互作用，这在家族成员中是保守的，但我们的数据表明ANA的羧基末端一半在相互作用中起作用。最后，原位杂交实验表明，Caf 1的表达重叠至少部分与ANA。因此，ANA可以通过与Caf 1相互作用发挥作用。
A 35‐kDa protein, ANA, belongs to an emerging family of antiproliferative proteins consisting of Tob, Tob2, ANA/BTG3, PC3B, PC3/TIS21/BTG2, and BTG1. All of these, except ANA and PC3B, have been shown to interact with the CCR4 transcription factor‐associated protein Cafl. Here we show that ANA also associates with Cafl, ANA being the preferred partner of Cafl among the Tob family proteins. Although ANA is likely to interact with Cafl at its amino‐terminal hall', which is conserved among the family members, our data suggest that the carboxyl‐terminal half of ANA plays a role in the interaction. Finally, in situ hybridization experiments revealed that expression of Caf1 overlaps at least in part with that of ANA. Thus, ANA could function through its interaction with Caf1.
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64.5
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