Percutaneous Absorption and Principles of Corneotherapy/Skin Care
Percutaneous Absorption and Principles of Corneotherapy/Skin Care
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经皮吸收和角膜治疗/皮肤护理原理
DOI：
10.1007/978-3-540-78814-0_6
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
H. Tagami
中科院分区：
文献类型：
--
作者：
H. Tagami
那些分子量大于500 Da的物质几乎不能穿透作为皮肤屏障的仅10 mm厚的SC所覆盖的皮肤。
SC屏障功能取决于其独特的细胞间脂质的存在，这些脂质与成熟的角质细胞紧密结合，其形成在患病皮肤中受到干扰。
SC屏障功能是不均匀的，并且在面部和生殖器皮肤中具有极差屏障功能的不同身体部位之间存在很大差异。
通过毛囊和汗管的旁路途径渗透可以允许外部施加的物质快速但仅少量地渗透。
由闭塞引起的过度SC水合导致角质细胞肿胀，从而导致所施用药物的经皮吸收增加几倍至十倍以上。
正常SC结合水以保持皮肤表面光滑和柔软，与病理性SC相比，病理性SC具有产生鳞状或破裂皮肤表面的缺乏水结合能力。
角膜治疗包括每日应用高度保湿剂，不仅诱导皮肤表面水合作用的持久增加，而且修复轻度SC屏障功能障碍，如特应性干燥症中所述。
Those substances with a molecular weight larger than 500 Da can hardly penetrate through the skin covered by just a 10- mm thick SC as skin barrier.
The SC barrier function depends on the presence of its unique intercellular lipids that are tightly bound to maturated corneocytes, whose formation is disturbed in diseased skin.
The SC barrier function is not uniform and greatly differs among various body locations with extremely poor barrier function in the face and genital skin.
The bypass pathway penetration through hair follicles and sweat ducts may allow quick but only small amount of penetration of externally applied substances.
Excessive SC hydration induced by occlusion causes swelling of the corneocytes to lead to several to more than tenfold increase in percutaneous absorption of applied drugs.
Normal SC binds water to keep the skin surface smooth and soft in contrast to pathologic SC with deficient water-binding capacity that produces a scaly or cracked skin surface.
Corneotherapy consisting of daily applications of a highly moisturizing agent not only induces long-lasting increase in skin surface hydration but also repairs mild SC barrier dysfunction such as noted in atopic xerosis.
影响因子：
3.6
作者：
C. Chuong;Nickoloff Bj;P. Elias;Lowell A. Goldsmith;E. Macher;Maderson Pa;J. P. Sundberg;Hachiro T
通讯作者：
C. Chuong;Nickoloff Bj;P. Elias;Lowell A. Goldsmith;E. Macher;Maderson Pa;J. P. Sundberg;Hachiro T