The Association Between Chlamydia pneumoniae and Metabolic Syndrome in Taiwanese Adults
The Association Between Chlamydia pneumoniae and Metabolic Syndrome in Taiwanese Adults
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台湾成人肺炎衣原体与代谢综合症的关联
DOI：
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
How
中科院分区：
文献类型：
--
作者：
Ching;S. Su;Chih‐Ching Chang;Tsung;J. Shieh;How
目的：肺炎衣原体（Cp）血清阳性和代谢综合征（MeS）已被确定为动脉粥样硬化和心血管疾病（CVD）的危险因素，但Cp血清阳性和MeS之间的关联尚未得到广泛研究。背景：我们从台湾成年人中招募参与者，他们在医疗机构接受年度健康检查。我们通过酶联免疫吸附试验测定抗Cp IgG抗体（Cp-IgG），并使用20 RU/mL作为临界点定义Cp-IgG血清阳性。结果：在3633名研究参与者中，总体Cp-IgG血清阳性率为45.5%。男性、高龄、白色领、吸烟、糖尿病、高血压与Cp-IgG阳性率相关（P<0.05）。MeS组Cp-IgG阳性率（62.8%）高于MeS组（37.2%）（P <0.001）。多因素Logistic回归分析显示，Cp-IgG阳性（OR =1.4，95%CI：1.1-1.9）、男性（OR=5.0，95%CI：3.3-7.6）和年龄较大（OR=2.6，95%CI：1.1-6.1（≥ 40岁））是MeS的独立预测因素。结论：Cp血清阳性与MeS呈正相关，这支持了感染在动脉粥样硬化和CVD发病机制中的作用。
Objective: Both Chlamydia pneumoniae (Cp) seropositivity and metabolic syndrome (MeS) have been identified as risk factors for atherosclerosis and cardiovascular disease (CVD), but the association between Cp seropositivity and MeS has not been extensively studied. Background: We recruited participants from Taiwanese adults who received an annual health examination at a medical facility. We measured anti-Cp IgG antibodies (Cp-IgG) by enzyme-linked immunosorbent assay and defined Cp-IgG seropositivity using 20 RU/mL as the cutoff point. Results: In the 3633 study participants, the overall Cp-IgG seropositive rate was 45.5%. Male gender, older age, white collar jobs, smoking, diabetes mellitus, and hypertension were associated with a higher Cp-IgG seropositive rate (P<0.05). Participants with MeS had a higher Cp-IgG seropositive rate (62.8% vs. 37.2%, P <0.001). Multiple logistic regression revealed that positive Cp-IgG (odds ratio [OR]=1.4, 95% confidence interval [CI]: 1.1–1.9), male gender (OR=5.0, 95% CI: 3.3–7.6) and older age(OR=2.6, 95% CI: 1.1–6.1 for age ≥ 40 years old) were independent predictors for MeS. Conclusion: There is a positive association between Cp seropositivity and MeS, which supports the role of infection in the pathogenesis of atherosclerosis and CVD.
DOI：
10.1056/nejm199906173402418
发表时间：
1999-06
期刊：
The New England journal of medicine
影响因子：
--
作者：
Williams Kj;I. Tabas
通讯作者：
Williams Kj;I. Tabas
影响因子：
6.5
作者：
V. Cabana;Joan N. Siegel;S. Sabesin
通讯作者：
V. Cabana;Joan N. Siegel;S. Sabesin