The fine-scale landscape of immunity and parasitism in a wild ungulate population
The fine-scale landscape of immunity and parasitism in a wild ungulate population
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野生有蹄类动物种群免疫和寄生的精细景观
DOI：
10.1101/483073
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Albery G
中科院分区：
文献类型：
--
作者：
Albery G
寄生虫易感性和暴露的空间异质性是疾病生态学研究中混杂变异的常见来源。然而，目前尚不清楚空间自相关是否在小尺度上对野生动物种群内的免疫力起作用，以及这是否预测了感染的空间模式。在这里，我们使用了一个很好的混合野生人口的个别承认红鹿（马鹿）居住在一个异质性景观，调查细尺度的空间格局的免疫和寄生。我们非侵入性地收集了842个粪便样本，从141名女性已知的范围行为超过2年。我们定量总和蠕虫特异性粘膜抗体和计数繁殖的三个胃肠道蠕虫类群。使用集成嵌套拉普拉斯近似，使用随机偏微分方程方法控制和量化空间自相关，使用线性混合模型分析这些数据。我们还调查了免疫和寄生的空间格局是否随季节变化。我们发现了大量的空间异质性一般和蠕虫特异性抗体水平和寄生虫与两个蠕虫类群，所有这些都表现出鲜明的季节性变化，其空间格局。值得注意的是，片形吸虫hepaticaintensity似乎是强烈影响的存在下，潮湿的放牧区，抗体热点没有相关的任何寄生虫的分布。我们的研究结果表明，空间异质性可能是一个重要的因素，影响免疫和寄生在广泛的研究系统。我们讨论了这些结果与设计的抽样制度和公共卫生干预措施，并建议疾病生态学研究调查的空间异质性更经常地提高他们的结果，即使在检查小的地理区域。
Spatial heterogeneity in susceptibility and exposure to parasites is a common source of confounding variation in disease ecology studies. However, it is not known whether spatial autocorrelation acts on immunity at small scales, within wild animal populations, and whether this predicts spatial patterns in infection. Here we used a well-mixed wild population of individually recognized red deer (Cervus elaphus) inhabiting a heterogeneous landscape to investigate fine-scale spatial patterns of immunity and parasitism. We noninvasively collected 842 fecal samples from 141 females with known ranging behavior over 2 years. We quantified total and helminth-specific mucosal antibodies and counted propagules of three gastrointestinal helminth taxa. These data were analyzed with linear mixed models using the Integrated Nested Laplace Approximation, using a Stochastic Partial Differentiation Equation approach to control for and quantify spatial autocorrelation. We also investigated whether spatial patterns of immunity and parasitism changed seasonally. We discovered substantial spatial heterogeneity in general and helminth-specific antibody levels and parasitism with two helminth taxa, all of which exhibited contrasting seasonal variation in their spatial patterns. Notably,Fasciola hepaticaintensity appeared to be strongly influenced by the presence of wet grazing areas, and antibody hotspots did not correlate with distributions of any parasites. Our results suggest that spatial heterogeneity may be an important factor affecting immunity and parasitism in a wide range of study systems. We discuss these findings with regards to the design of sampling regimes and public health interventions, and suggest that disease ecology studies investigate spatial heterogeneity more regularly to enhance their results, even when examining small geographic areas.
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东非短角瘤牛犊圆线虫感染的变异和共变异
影响因子：
2.4
作者：
R. Callaby;O. Hanotte;I. V. Wyk;H. Kiara;P. Toye;M. Mbole;A. Jennings;S. Thumbi;J. Coetzer;B. Bronsvoort;S. Knott;M. Woolhouse;L. Kruuk
通讯作者：
L. Kruuk
澳大利亚瞌睡蜥蜴（Tiliqua rugosa）种群中肠沙门氏菌亚种的空间变异和生存
影响因子：
4.4
作者：
S. Parsons;C. Michael Bull;David M. Gordon
通讯作者：
David M. Gordon
寄生虫及其影响。
DOI：
--
发表时间：
2004
期刊：
影响因子：
--
作者：
K. Wilson;B. Grenfell;J. Pilkington;H. Boyd;F. Gulland
通讯作者：
F. Gulland
罗姆尼羊粪便卵数和生产力性状的遗传力和遗传相关性
影响因子：
1.8
作者：
S. Bisset;A. Vlassoff;C. Morris;Southey Br;R. L. Baker;A. Parker
通讯作者：
A. Parker
DOI：
10.1073/pnas.1518046113
发表时间：
2016-03-29
影响因子：
11.1
作者：
Huisman, Jisca;Kruuk, Loeske E. B.;Pemberton, Josephine M.
通讯作者：
Pemberton, Josephine M.