Serologic responses of 42 MERS-coronavirus-infected patients according to the disease severity.
Serologic responses of 42 MERS-coronavirus-infected patients according to the disease severity.
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DOI：
10.1016/j.diagmicrobio.2017.07.006
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发表时间：
2017-10
影响因子：
2.9
通讯作者：
Peck KR
中科院分区：
文献类型：
--
作者：
Ko JH;Müller MA;Seok H;Park GE;Lee JY;Cho SY;Ha YE;Baek JY;Kim SH;Kang JM;Kim YJ;Jo IJ;Chung CR;Hahn MJ;Drosten C;Kang CI;Chung DR;Song JH;Kang ES;Peck KR
我们将42例中东呼吸综合征冠状病毒（MERS-CoV）感染患者分为4个严重程度组：无症状感染（0组）、无肺炎症状感染（1组）、肺炎无呼吸衰竭（2组）和肺炎进展为呼吸衰竭（3组）。0组患者均无血清转化，血清转化率随病情加重逐渐升高（0、1、2、3组分别为0.0%、60.0%、93.8%、100%,P = 0.001）。第3组患者抗体滴度在第4周出现延迟增加，而第2组患者抗体滴度在第3周出现强劲增加。在肺炎患者中，75%的死亡患者在第三周未出现血清转化，而100%的存活患者血清转化（P = 0.003）。对42例mers - cov感染患者的血清学反应进行了评价。将患者分为4个疾病严重程度组。血清转换率随疾病严重程度的增加而逐渐升高。75%的死亡患者在第三周没有出现血清转化。
We evaluated serologic response of 42 Middle East respiratory syndrome coronavirus (MERS-CoV)-infected patients according to 4 severity groups: asymptomatic infection (Group 0), symptomatic infection without pneumonia (Group 1), pneumonia without respiratory failure (Group 2), and pneumonia progressing to respiratory failure (Group 3). None of the Group 0 patients showed seroconversion, while the seroconversion rate gradually increased with increasing disease severity (0.0%, 60.0%, 93.8%, and 100% in Group 0, 1, 2, 3, respectively; P = 0.001). Group 3 patients showed delayed increment of antibody titers during the fourth week, while Group 2 patients showed robust increment of antibody titer during the third week. Among patients having pneumonia, 75% of deceased patients did not show seroconversion by the third week, while 100% of the survived patients were seroconverted (P = 0.003). Serologic responses of 42 MERS-CoV-infected patients were evaluated. Patients were divided into 4 disease severity groups. The seroconversion rate gradually increased with increasing disease severity. Seventy-five percent of deceased patients did not show seroconversion by the third week.
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影响因子：
11.8
作者：
Payne DC;Iblan I;Rha B;Alqasrawi S;Haddadin A;Al Nsour M;Alsanouri T;Ali SS;Harcourt J;Miao C;Tamin A;Gerber SI;Haynes LM;Al Abdallat MM
通讯作者：
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影响因子：
11.8
作者：
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影响因子：
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Kim YS
DOI：
10.1016/j.jinf.2016.08.005
发表时间：
2016-11
期刊：
The Journal of infection
影响因子：
--
作者：
Ko JH;Park GE;Lee JY;Lee JY;Cho SY;Ha YE;Kang CI;Kang JM;Kim YJ;Huh HJ;Ki CS;Jeong BH;Park J;Chung CR;Chung DR;Song JH;Peck KR
通讯作者：
Peck KR
1983 - 1997年，东非的骆驼中和冠状动脉中和抗体。
影响因子：
11.8
作者：
Müller MA;Corman VM;Jores J;Meyer B;Younan M;Liljander A;Bosch BJ;Lattwein E;Hilali M;Musa BE;Bornstein S;Drosten C
通讯作者：
Drosten C