Quo Vadis Botulinum Toxin: Normative Constraints and Quality of Life for Patients With Idiopathic OAB?
Quo Vadis Botulinum Toxin: Normative Constraints and Quality of Life for Patients With Idiopathic OAB?
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DOI：
10.3389/fsurg.2018.00061
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发表时间：
2018
影响因子：
1.8
通讯作者：
Fornara P
中科院分区：
文献类型：
--
作者：
Mühlstädt S;Mischner S;Kranz J;Anheuser P;Mohammed N;Steffens JA;Fornara P
背景资料：特发性膀胱过度活动症（iOAB），伴或不伴急迫性尿失禁（UI），对患者的生活质量（QoL）有显著的心理社会影响。iOAB的首选治疗方法是抗胆碱能药物，或者是β-3肾上腺素受体激动剂米拉贝隆。但是，这两种药物的全身副作用和禁忌症都应考虑。目的：我们报告了iOAB ± UI患者中肉毒杆菌毒素治疗（A型肉毒杆菌毒素，BOTOX®，Allergan）的疗效、安全性和对QoL的影响。患者和方法：在2005年至2013年期间，51例患者接受了onabotetravirus毒素A（100单位）治疗。入选标准为存在经证实的iOAB ± UI且既往使用过抗胆碱能药物。排尿频率、尿垫计数、排尿后残留量和生活质量使用两个经验证的问卷[客户满意度问卷-8（CSQ-8）和国王健康问卷（KHQ）]进行评价。用SPSS24.0进行统计学分析（p < 0.05）。结果：肉毒杆菌毒素注射后，观察到iOAB ± UI症状显著改善。排尿频率从10.4 ± 0.5次/天降至5.2 ± 0.4次/天（p = 0.026），尿垫计数从3.6 ± 1.0个/天降至1.2 ± 0.3个/天（p = 0.033）。肉毒杆菌毒素治疗期间未使用抗胆碱能药物。未观察到并发症和术后需要间歇性自我导管插入术（ISC）。总体而言，72%和24%的患者报告对治疗“满意”或“非常满意”。此外，66%的患者会再次选择肉毒杆菌毒素治疗iOAB。结论：肉毒毒素治疗iOAB是一种有效、安全和改善生活的治疗方法。
Background: Idiopathic overactive bladder (iOAB), with or without urge incontinence (UI), has significant psychosocial effects on patients' quality of life (QoL). The first choice of treatment for iOAB is anticholinergics and, alternatively, the β-3-adrenoceptor agonist mirabegron. However, systemic side effects and contraindications should be considered for both medications. Objective: We report the efficacy, safety and effects on QoL of botulinum toxin therapy (onabotulinum toxin type A, BOTOX®, Allergan) among patients with iOAB ± UI. Patients and Methods: Between 2005 and 2013, 51 patients were treated with onabotulinum toxin A (100 units). The inclusion criteria were the presence of confirmed iOAB ± UI with previous use of anticholinergic medication. Micturition frequency, pad count, postvoid residual volume and QoL were evaluated using two validated questionnaires [the Client Satisfaction Questionnaire-8 (CSQ-8) and the King's Health Questionnaire (KHQ)]. Statistical analysis was performed with SPSS 24.0 (p < 0.05). Results: After botulinum toxin injection, a significant improvement in iOAB ± UI symptoms was observed. The micturition frequency decreased from 10.4 ± 0.5 to 5.2 ± 0.4 micturitions per day (p = 0.026), and the pad count decreased from 3.6 ± 1.0 to 1.2 ± 0.3 pads per day (p = 0.033). Anticholinergics were not used during the administration of botulinum toxin therapy. Complications and postoperative need for intermittent self-catheterization (ISC) were not observed. Overall, 72 and 24% of patients reported being “satisfied” or “very satisfied” with the treatment. Additionally, 66% of patients would choose botulinum toxin again for the treatment of iOAB. Conclusion: Botulinum toxin therapy is an efficient, safe, and life-improving treatment for iOAB.
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影响因子：
23.4
作者：
Irwin, Debra E.;Milsom, Ian;Abrams, Paul
通讯作者：
Abrams, Paul
影响因子：
23.4
作者：
Chapple, Christopher;Sievert, Karl-Dietrich;Haag-Molkenteller, Cornelia
通讯作者：
Haag-Molkenteller, Cornelia
影响因子：
4.5
作者：
Malde, Sachin;Dowson, Christopher;Sahai, Arun
通讯作者：
Sahai, Arun
DOI：
10.1016/j.ejogrb.2011.03.020
发表时间：
2011-08-01
影响因子：
2.6
作者：
Abdel-fattah, Mohamed;Hasafa, Zaid;Mostafa, Alyaa
通讯作者：
Mostafa, Alyaa
影响因子：
2
作者：
Lai HH;Shen B;Rawal A;Vetter J
通讯作者：
Vetter J