The relationship between depression and overactive bladder/urinary incontinence symptoms in the clinical OAB population.
The relationship between depression and overactive bladder/urinary incontinence symptoms in the clinical OAB population.
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DOI：
10.1186/s12894-016-0179-x
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发表时间：
2016-10-06
期刊：
影响因子：
2
通讯作者：
Vetter J
中科院分区：
文献类型：
--
作者：
Lai HH;Shen B;Rawal A;Vetter J
调查临床 OAB 人群中抑郁症与膀胱过度活动症 (OAB)/尿失禁症状之间的关系。被诊断为膀胱过度活动症 (OAB) 的患者和年龄匹配的无 OAB 的对照受试者均纳入研究。使用医院焦虑和抑郁量表（HADS-D）评估抑郁症状。使用经过验证的问卷评估 OAB/失禁症状：ICIQ-UI、ICIQ-OAB、UDI-6、IIQ-7 和 OAB-q。在我们的研究中，27.5% 的 OAB 患者患有抑郁症（HADS ≥8），12% 的 OAB 患者患有中度至重度抑郁症（HADS-D ≥11）。与年龄匹配的对照组相比，OAB 患者的 HADS-D 抑郁评分显着较高（5.3±3.9 比 2.8±3.9，p=0.004）。与无抑郁症的 OAB 患者相比，患有抑郁症的 OAB 患者报告更严重的失禁症状 (ICIQ-UI)、更大的麻烦和对生活质量的更大影响 (UDI-6、IIQ-7)（分别为 p = 0.001、0.01、<0.001）。然而 ICIQ-OAB 和 OAB-q 没有差异。在 OAB 患者中，抑郁症状的严重程度与 OAB/失禁症状之间存在正相关（p 值 <0.001 至 0.035）。 27.5% 的 OAB 患者患有抑郁症。与那些没有抑郁症的患者相比，患有抑郁症的 OAB 患者尿失禁症状更严重，麻烦更大，对生活质量的影响更大。未来的研究需要进一步探讨抑郁症与 OAB/尿失禁之间的机制联系。
To investigate the relationship between depression and overactive bladder (OAB)/urinary incontinence symptoms among the clinical OAB population. Patients who were diagnosed with overactive bladder (OAB) and age-matched control subjects without OAB were enrolled. Depression symptoms were assessed using the Hospital Anxiety and Depression Scale (HADS-D). OAB/incontinence symptoms were assessed using the validated questionnaires: ICIQ-UI, ICIQ-OAB, UDI-6, IIQ-7, and OAB-q. 27.5 % of OAB patients in our study had depression (HADS ≥8), and 12 % of OAB patients had moderate to severe depression (HADS-D ≥11). OAB patients reported significantly higher HADS-D depression scores compared to age-matched controls (5.3 ± 3.9 versus 2.8 ± 3.9, p = 0.004). OAB patients with depression reported more severe incontinence symptoms (ICIQ-UI), greater bother and more impact on quality of life (UDI-6, IIQ-7) compared to OAB patients without depression (p = 0.001, 0.01, <0.001, respectively). However there were no differences in ICIQ-OAB and OAB-q. Among OAB patients, there were positive correlations between the severity of depression symptoms and OAB/incontinence symptoms (p-values <0.001 to 0.035). 27.5 % of OAB patients have depression. OAB patients with depression reported more severe urinary incontinence symptoms, greater bother and more impact on quality of life compared to those without depression. Future studies are needed to further examine the mechanistic links between depression and OAB/urinary incontinence.
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DOI：
10.1097/spv.0000000000000062
发表时间：
2014-09-01
影响因子：
1.6
作者：
Levin, Pamela June;Siddiqui, Nazema Yusuf;Amundsen, Cindy Louise
通讯作者：
Amundsen, Cindy Louise
影响因子：
4.5
作者：
Steers, William D.;Herschorn, Sender;Bump, Richard C.
通讯作者：
Bump, Richard C.
影响因子：
3.5
作者：
Coyne, K;Revicki, D;Abrams, P
通讯作者：
Abrams, P
影响因子：
9.8
作者：
Melville, JL;Walker, E;Fenner, D
通讯作者：
Fenner, D
影响因子：
6.6
作者：
Zorn, BH;Montgomery, H;Steers, WD
通讯作者：
Steers, WD