Whole-brain vessel wall MRI: A parameter tune-up solution to improve the scan efficiency of three-dimensional variable flip-angle turbo spin-echo.
Whole-brain vessel wall MRI: A parameter tune-up solution to improve the scan efficiency of three-dimensional variable flip-angle turbo spin-echo.
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DOI：
10.1002/jmri.25611
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发表时间：
2017-09
期刊：
影响因子：
--
通讯作者：
Fan Z
中科院分区：
文献类型：
--
作者：
Yang Q;Deng Z;Bi X;Song SS;Schlick KH;Gonzalez NR;Li D;Fan Z
提出并评价一种参数调整解决方案，以加快全脑颅内血管壁（IVW）成像的三维（3D）可变翻转角快速自旋回波（TSE）序列。椭圆k空间采样和延长的回波链长度（ETL）被用于加速基于3D可变翻转角TSE的序列。为了补偿血管壁信号的潜在损失，在3 T下对22名健康志愿者进行了处方T2和ETL的最佳组合的实验研究。然后在10名健康志愿者中，在信噪比（SNR）、对比度噪声比（CNR）、血管壁清晰度和血管壁描绘质量方面，以4分制（0：差; 3：优）比较优化方案（7-8分钟）与先前方案（参考方案，11-12分钟）。对5例患者进行了初步研究，并使用病变勾画评分来证明诊断质量。ETL=52和规定的T2= 170 ms的方案被认为是优化的方案，与参考方案相比，其提供了显著改善的壁SNR（12.0±1.3 vs. 10.0±1.1，p=0.002），壁腔CNR（9.7±1.2 vs. 8.0±0.9，p=0.002），壁-CSF CNR（2.8±1.0 vs. 1.7±1.0，p=0.026），两个内、外表面的血管壁锐度相似（1.59±0.18 vs 1.58±0.14，p=0.87）和外部（1.71±0.25 vs 1.83±0.30，p=0.18）边界，单个节段的血管壁描绘评分相当（1.95-3，p>0.06）。在所有患者中，动脉粥样硬化斑块（10例）或壁夹层（5例）的界定评分为3或2。参数调整解决方案可以加速3D可变翻转角TSE采集，特别是允许在保持壁描绘质量的情况下加速全脑IVW成像。
To propose and evaluate a parameter tune-up solution to expedite a three-dimensional (3D) variable-flip-angle turbo spin-echo (TSE) sequence for whole-brain intracranial vessel wall (IVW) imaging. Elliptical k-space sampling and prolonged echo train length (ETL), were used to expedite a 3D variable-flip-angle TSE-based sequence. To compensate for the potential loss in vessel wall signal, optimal combination of prescribed T2 and ETL was experimentally investigated on 22 healthy volunteers at 3T. The optimized protocol (7–8 minutes) was then compared with a previous protocol (reference protocol, 11–12 minutes) in terms of signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), vessel wall sharpness, and wall delineation quality on a 4-point scale (0:poor; 3:excellent) in 10 healthy volunteers. A pilot study of 5 patients was performed and lesion delineation score was used to demonstrate the diagnostic quality. A protocol with ETL=52 and prescribed T2=170ms was deemed an optimized one, which, compared to the reference protocol, provided significantly improved wall SNR (12.0±1.3 vs. 10.0±1.1, p=0.002), wall-lumen CNR (9.7±1.2 vs. 8.0±0.9, p=0.002), wall-CSF CNR (2.8±1.0 vs. 1.7±1.0, p=0.026), similar vessel wall sharpness at both inner (1.59±0.18 vs 1.58±0.14, p=0.87) and outer (1.71±0.25 vs. 1.83±0.30, p=0.18) boundaries, and comparable vessel wall delineation score for individual segments (1.95–3, p>0.06). In all patients, atherosclerotic plaques (10) or wall dissection (5) were identified with a delineation score of 3 or 2. A parameter tune-up solution can accelerate 3D variable-flip-angle TSE acquisitions, particularly allowed for expedited whole-brain IVW imaging with preserved wall delineation quality.
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影响因子：
3.3
作者：
Busse, Reed F.;Brau, Anja C. S.;Vu, Anthony;Michelich, Charles R.;Bayram, Ersin;Kijowski, Richard;Reeder, Scott B.;Rowley, Howard A.
通讯作者：
Rowley, Howard A.
影响因子：
3.3
作者：
Viessmann O;Li L;Benjamin P;Jezzard P
通讯作者：
Jezzard P
DOI：
10.1136/jnnp-2015-312020
发表时间：
2016-06
期刊：
Journal of neurology, neurosurgery, and psychiatry
影响因子：
--
作者：
Alexander MD;Yuan C;Rutman A;Tirschwell DL;Palagallo G;Gandhi D;Sekhar LN;Mossa-Basha M
通讯作者：
Mossa-Basha M
影响因子：
3.5
作者：
Sakurai, Keita;Miura, Toshiyasu;Shibamoto, Yuta
通讯作者：
Shibamoto, Yuta
影响因子：
19.7
作者：
Li, DB;Carr, JC;Finn, JP
通讯作者：
Finn, JP