Macrophage targeted theranostics as personalized nanomedicine strategies for inflammatory diseases.
Macrophage targeted theranostics as personalized nanomedicine strategies for inflammatory diseases.
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DOI：
10.7150/thno.9476
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发表时间：
2015
期刊：
影响因子：
12.4
通讯作者：
Janjic JM
中科院分区：
文献类型：
--
作者：
Patel SK;Janjic JM
由于炎症的复杂性和患者固有的变异性，炎症性疾病的管理带来了挑战，因此需要针对患者的治疗干预。Theranostics集治疗和成像功能于一体，可用于同时成像和治疗炎症性疾病。Theranostics可以促进安全性、毒性和实时治疗效果的评估，从而产生个性化的治疗策略。巨噬细胞是炎症性疾病的重要细胞成分，参与疾病加重和消退的多种角色。巨噬细胞固有的吞噬性质、丰度和疾病归巢特性可以作为成像和治疗目的的靶点。这篇综述讨论了治疗药物在巨噬细胞消融、表型调节和抑制其炎症活性从而在几种疾病中消退炎症方面的应用。
Inflammatory disease management poses challenges due to the complexity of inflammation and inherent patient variability, thereby necessitating patient-specific therapeutic interventions. Theranostics, which integrate therapeutic and imaging functionalities, can be used for simultaneous imaging and treatment of inflammatory diseases. Theranostics could facilitate assessment of safety, toxicity and real-time therapeutic efficacy leading to personalized treatment strategies. Macrophages are an important cellular component of inflammatory diseases, participating in varied roles of disease exacerbation and resolution. The inherent phagocytic nature, abundance and disease homing properties of macrophages can be targeted for imaging and therapeutic purposes. This review discusses the utility of theranostics in macrophage ablation, phenotype modulation and inhibition of their inflammatory activity leading to resolution of inflammation in several diseases.
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