Blood neurofilament light chain and total tau levels at admission predict death in COVID-19 patients.
Blood neurofilament light chain and total tau levels at admission predict death in COVID-19 patients.
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DOI：
10.1007/s00415-021-10595-6
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发表时间：
2021-12
影响因子：
6
通讯作者：
Furlan R
中科院分区：
文献类型：
--
作者：
De Lorenzo R;Loré NI;Finardi A;Mandelli A;Cirillo DM;Tresoldi C;Benedetti F;Ciceri F;Rovere-Querini P;Comi G;Filippi M;Manfredi AA;Furlan R
感染SARS-CoV-2的患者从无症状到轻度、中度或重度疾病演变，包括致命结局。因此，临床结果的早期预测是非常必要的。我们研究了神经组织损伤的标志物作为多系统受累的可能早期体征，以评估其对生存或转移到重症监护室（ICU）的临床预后价值。 我们收集了104例SARS-CoV-2感染患者入院当天的血液，并测量了血液神经丝光椅（NfL），胶质细胞酸性蛋白（GFAP），泛素羧基末端水解酶L1（UCH-L1）和总tau蛋白水平。我们发现，NfL、GFAP和tau蛋白在有致死性结局的患者中显著增加，而NfL和UCH-L1在需要ICU转移的患者中显著增加。ROC和Kaplan-Meier曲线表明，入院时总tau水平准确预测死亡率。血液神经标志物可能为用于预测COVID-19结局的传统生物标志物提供额外的预后价值。 在线版本包含补充材料，可通过10.1007/s 00415 -021-10595-6获得。
Patients infected with SARS-CoV-2 range from asymptomatic, to mild, moderate or severe disease evolution including fatal outcome. Thus, early predictors of clinical outcome are highly needed. We investigated markers of neural tissue damage as a possible early sign of multisystem involvement to assess their clinical prognostic value on survival or transfer to intensive care unit (ICU). We collected blood from 104 patients infected with SARS-CoV-2 the day of admission to the emergency room and measured blood neurofilament light chair (NfL), glial fibrillary acidic protein (GFAP), ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), and total tau protein levels. We found that NfL, GFAP, and tau were significantly increased in patients with fatal outcome, while NfL and UCH-L1 in those needing ICU transfer. ROC and Kaplan–Meier curves indicated that total tau levels at admission accurately predict mortality. Blood neural markers may provide additional prognostic value to conventional biomarkers used to predict COVID-19 outcome. The online version contains supplementary material available at 10.1007/s00415-021-10595-6.
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