İdrar interlökin-13, CD80, CD28, matriks metaloproteinaz-2 ve granzim B‘nin çocukluk çağı minimal değişim nefrotik sendrom patogenezindeki rolleri
İdrar interlökin-13, CD80, CD28, matriks metaloproteinaz-2 ve granzim B‘nin çocukluk çağı minimal değişim nefrotik sendrom patogenezindeki rolleri
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Idrar interlökin-13、CD80、CD28、金属蛋白基质 2 和 granzim B‘nin çocukluk çağı 最小 değişim nefrotik sendrom patogenezindeki rolli
DOI：
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
Faysal Gok
中科院分区：
文献类型：
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作者：
Cengiz Zeybek;Duygu Övünç Hacıhamdioğlu;S. Yavuz;Aysel Pekel;Cihangir Akgün;Burcu Bulum;Kaan Gulleroglu;Aslı Kantar;A. Kavaz;U. Muşabak;F. Yalçinkaya;Esra Baskin;Faysal Gok
目的：微小改变病（MCD）是儿童肾病综合征最常见的病因，但其发病机制尚不清楚。一种或多种t细胞衍生的因子最初被认为与疾病的发病机制有关。然而，足细胞CD80的表达现在是一个普遍讨论的理论。本研究的目的是通过检测尿中白细胞介素-13、CD80、CD28、基质金属蛋白酶-2 （MMP-2）和颗粒酶B水平来探讨MCD的发病机制。方法：对30例患者和30例健康儿童进行评价。6例活检证实MCD。其余的患者被认为患有MCD，因为他们在诊断时的年龄；对类固醇治疗有反应，无明显血尿、补体不足或肾功能衰竭；活动期血压正常。将所有患者肾期尿白细胞介素-13、CD80、CD28、MMP-2和颗粒酶B水平与同一患者和对照组缓解期尿水平进行比较。在使用免疫抑制药物或其他治疗方式之前立即收集尿液样本。结果：复发期患者白细胞介素-13、CD80、CD28、MMP-2水平均高于缓解期和对照组。活动期尿白细胞介素-13与CD80水平呈显著正相关(r=0.619, p
Objective: Minimal change disease (MCD) is the most common cause of nephrotic syndrome in childhood but its pathogenesis remains poorly understood. A T-cell-derived factor or factors were initially alleged as contributing to the disease pathogenesis. However, podocyte CD80 expression is now a commonly discussed theory. The aim of this study was to investigate the pathogenesis of MCD by determining urine interleukin-13, CD80, CD28, matrix metalloproteinase-2 (MMP-2), and granzyme B levels. Methods: Thirty patients and thirty healthy children were evaluated in this study. Six patients had biopsy proven MCD. The remaining patients were considered to have MCD because of their age at time of diagnosis; response to steroid treatment, absence of gross hematuria, hypocomplementemia or renal failure; and normal blood pressures in the active stage. The nephrotic-phase urine interleukin-13, CD80, CD28, MMP-2, and granzyme B levels of all patients were compared with the remission-stage urine levels of the same patients and control subjects. The urine samples were collected immediately before the application of immunosuppressive drugs or other treatment modalities. Results: Significantly higher interleukin-13, CD80, CD28, and MMP-2 levels were observed in the relapse period compared with both the remission period and control subjects. There was a significant positive correlation between the active-stage urine interleukin-13 and CD80 levels (r=0.619, p
影响因子：
2.2
作者：
Vignali, DAA
通讯作者：
Vignali, DAA
影响因子：
13.6
作者：
Schwartz, George J.;Munoz, Alvaro;Furth, Susan L.
通讯作者：
Furth, Susan L.
影响因子：
13.6
作者：
Garin, Eduardo H.;Diaz, Leila N.;Johnson, Richard J.
通讯作者：
Johnson, Richard J.