Evidence for operation of the direct zinc ligand exchange mechanism for trafficking, transport, and reactivity of zinc in mammalian cells.
Evidence for operation of the direct zinc ligand exchange mechanism for trafficking, transport, and reactivity of zinc in mammalian cells.
复制标题
直接锌配体交换机制运行的证据，用于哺乳动物细胞中锌的运输，运输和反应性。
DOI：
10.1016/j.jinorgbio.2011.02.002
复制
发表时间：
2011-05
影响因子：
3.9
通讯作者：
Franklin, Renty B.
中科院分区：
文献类型：
--
作者：
Costello, Leslie C.;Fenselau, Catherine C.;Franklin, Renty B.
除了在正常细胞功能、生长和代谢中发挥关键作用外，锌还是许多病理状况和疾病发生和进展的主要因素。尽管锌如此重要，但锌的生理学、生物化学和分子生物学的许多重要因素、过程和机制仍然未知。尤其重要的是有关细胞中锌的运输、运输和反应性的机制和过程的尚未解决的问题；尤其是在哺乳动物细胞中。本演讲重点讨论的概念是，由于哺乳动物细胞环境中存在可忽略不计的游离 Zn2+ 离子池，因此锌的运输、运输和反应性是通过锌从供体 Zn-配体到受体配体的直接交换而发生的。这种 Zn 交换过程不需要产生游离 Zn2+ 离子。来自哺乳动物细胞研究的直接证据支持直接锌配体交换机制的运作。本文还提供了在进行有关锌在生物/生物医学研究中的作用和影响的研究时应考虑和采用的重要信息和条件；及其临床解释和应用。
In addition to its critical role in normal cell function, growth, and metabolism, zinc is implicated as a major factor in the development and progression of many pathological conditions and diseases. Despite this importance of zinc, many important factors, processes, and mechanisms of the physiology, biochemistry, and molecular biology of zinc remain unknown. Especially important is the unresolved issue regarding the mechanism and process of the trafficking, transport, and reactivity of zinc in cells; especially in mammalian cells. This presentation focuses on the concept that, due to the existence of a negligible pool of free Zn2+ ions in the mammalian cell environment, the trafficking, transport and reactivity of zinc occurs via a direct exchange of zinc from donor Zn-Ligands to acceptor ligands. This Zn exchange process occurs without the requirement for production of free Zn2+ ions. The direct evidence from mammalian cell studies is presented in support of the operation of the direct Zn-Ligand exchange mechanism. The paper also provides important information and conditions that should be considered and employed in the conduct of studies regarding the role and effects of zinc in biological/biomedical research; and in its clinical interpretation and application.
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DOI：
10.1016/j.bbrc.2005.04.170
发表时间：
2005-07-08
影响因子：
3.1
作者：
Feng, W;Cai, J;Kang, YJ
通讯作者：
Kang, YJ
影响因子：
3.9
作者：
Franklin, RB;Ma, J;Costello, LC
通讯作者：
Costello, LC
影响因子：
4.8
作者：
Gaither, LA;Eide, DJ
通讯作者：
Eide, DJ
影响因子：
1.8
作者：
Hathout, Y;Fabris, D;Fenselau, C
通讯作者：
Fenselau, C
影响因子：
3.9
作者：
Costello, LC;Franklin, RB;Kennedy, MC
通讯作者：
Kennedy, MC