Glioma infiltration of the corpus callosum: early signs detected by DTI.
Glioma infiltration of the corpus callosum: early signs detected by DTI.
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DOI：
10.1007/s11060-013-1049-y
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发表时间：
2013-04
影响因子：
3.9
通讯作者：
Knauth, M.
中科院分区：
文献类型：
--
作者：
Kallenberg, K.;Goldmann, T.;Menke, J.;Strik, H.;Bock, H. C.;Stockhammer, F.;Buhk, J. H.;Frahm, J.;Dechent, P.;Knauth, M.
最常见的原发性脑肿瘤，间变性星形细胞瘤（AA）和胶质母细胞瘤（GBM）：倾向于侵犯周围脑。组织学研究发现，在远离原发肿瘤的肉眼未怀疑的脑实质中存在恶性细胞，甚至影响对侧半球。在早期阶段，弥漫性神经间浸润的表观扩散系数（ADC）和各向异性分数（FA）的变化是可疑的。本研究的目的是探讨DTI作为一种可能的工具描绘肿瘤侵入胼胝体（CC）的证据的价值。术前，31例高级别脑肿瘤患者（8例AA和23例GBM）接受了3 T MRI检查，应用高分辨率扩散张量成像（DTI）序列。ADC值和FA值在CC的肿瘤相关区域中进行分析，如通过纤维追踪所确定的，并与匹配的健康对照进行比较。在（MR-）形态正常的CC中，肿瘤患者的ADC值（n = 22; 0.978 × 10−3 mm²/s）高于匹配对照组（0.917 × 10− 3 mm²/s，p < 0.05），相应的相对FA降低（rFA：88%，p < 0.01）。在MRI上可见CC病变的情况下，效果明显（n = 9; 0.978 × 10−3 mm²/s，p < 0.05; rFA：72%，p < 0.01）。CC中扩散率和各向异性的变化可以解释为肿瘤扩散到对侧半球的指标，在常规MRI上不可见。
The most frequent primary brain tumors, anaplastic astrocytomas (AA) and glioblastomas (GBM): tend to invasion of the surrounding brain. Histopathological studies found malignant cells in macroscopically unsuspicious brain parenchyma remote from the primary tumor, even affecting the contralateral hemisphere. In early stages, diffuse interneural infiltration with changes of the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) is suspected. The purpose of this study was to investigate the value of DTI as a possible instrument of depicting evidence of tumor invasion into the corpus callosum (CC). Preoperatively, 31 patients with high-grade brain tumors (8 AA and 23 GBM) were examined by MRI at 3 T, applying a high-resolution diffusion tensor imaging (DTI) sequence. ADC- and FA-values were analyzed in the tumor-associated area of the CC as identified by fiber tracking, and were compared to matched healthy controls. In (MR-)morphologically normal appearing CC the ADC values were elevated in the tumor patients (n = 22; 0.978 × 10−3 mm²/s) compared to matched controls (0.917 × 10−3 mm²/s, p < 0.05), and the corresponding relative FA was reduced (rFA: 88 %, p < 0.01). The effect was pronounced in case of affection of the CC visible on MRI (n = 9; 0.978 × 10−3 mm²/s, p < 0.05; rFA: 72 %, p < 0.01). Changes in diffusivity and anisotropy in the CC can be interpreted as an indicator of tumor spread into the contralateral hemisphere not visible on conventional MRI.
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影响因子：
3.9
作者：
Kageji, T;Nagahiro, S;Nakagawa, Y
通讯作者：
Nakagawa, Y
影响因子：
4.1
作者：
Silbergeld, DL;Chicoine, MR
通讯作者：
Chicoine, MR
影响因子：
19.7
作者：
Kallenberg, Kai;Bock, Hans C.;Knauth, Michael
通讯作者：
Knauth, Michael
影响因子：
1.1
作者：
Price, SJ;Peña, A;Gillard, JH
通讯作者：
Gillard, JH
影响因子：
3.9
作者：
Geer, CP;Grossman, SA
通讯作者：
Grossman, SA