Cardiopulmonary resuscitation in veno-venous-ECMO patients-A retrospective study on incidence, causes and outcome.

Cardiopulmonary resuscitation in veno-venous-ECMO patients-A retrospective study on incidence, causes and outcome.
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静脉-静脉- ecmo患者心肺复苏的发生率、原因和结果的回顾性研究。

DOI:
10.1371/journal.pone.0290083
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发表时间:
2023
期刊:
影响因子:
3.7
通讯作者:
--
中科院分区:
综合性期刊3区
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--
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尽管始终存在最佳资源,但现代重症监护病房 (ICU) 中的心脏骤停与不良结果相关。目前尚无越来越多接受静脉-静脉-体外膜肺氧合 (VV-ECMO) 患者的心脏骤停 (CA) 数据。由于该手术具有高度侵入性,与没有 ECMO 的 ICU 人群相比,预计还会出现其他心脏骤停的发生率和原因。本研究重点关注 VV-ECMO 治疗下的心脏骤停。回顾性单中心观察研究,包括 2019 年 1 月 1 日至 2022 年 3 月 31 日期间的所有 VV-ECMO 患者。本研究的主要重点是 VV-ECMO 治疗期间 CA 的数量和原因。次要终点是治疗过程、并发症和结果。研究期间有 140 名患者接受了 VV-ECMO 治疗。其中,23 名患者在 VV-ECMO 治疗期间出现 29 例 CA,需要进行心肺复苏 (CPR)。近一半的 CA (48%;n = 14) 发生在医疗手术期间,21% (n = 6) 与设备相关。无脉电活动 (PEA) 是心肺复苏开始时最常见的心律 (72%)。 86% 的患者实现了自主循环 (ROSC),两次 CA (6.9%) 进行了体外心肺复苏。心肺复苏后出院存活率为 13%。在接受 VV-ECMO 治疗的所有患者中,超过 15% 的患者发生 CA。 VV-ECMO 期间的医疗程序与 CA 的高风险相关,应谨慎规划。此外,ROSC 率非常高,只有少数患者在整个 VV-ECMO 治疗过程中存活下来。
Cardiac arrest in a modern intensive care unit (ICU) is associated with poor outcome although optimal resources are present at all times. Data on cardiac arrest (CA) of the increasing cohort of patients with veno-venous-extracorporeal membrane oxygenation (VV-ECMO) are not available. Due to the highly invasive nature of this procedure, other incidences and causes of cardiac arrest are expected when compared to the ICU population without ECMO. This study focuses on cardiac arrest under VV-ECMO treatment. Retrospective single-center observational study including all VV-ECMO patients from 1st January 2019 until 31st March 2022. Primary focus of this study was number and causes for CA during VV-ECMO treatment. Secondary endpoints were treatment procedure, complications and outcome. 140 patients were treated with VV-ECMO in the study period. Of those, 23 patients had 29 CA with need for cardiopulmonary resuscitation (CPR) during VV-ECMO treatment. Nearly half of all CA (48%; n = 14) occurred during medical procedures and 21% (n = 6) were device related. Pulseless electric activity (PEA) was the most common rhythm upon CPR initiation (72%). ROSC was achieved in 86%, two CA (6.9%) resulted in extracorporeal CPR. Survival to hospital discharge was 13% following CPR. CA occurs in over 15% of all patients treated with a VV-ECMO. Medical procedures during VV-ECMO are associated with a high risk of CA and should be planned with care. Also, the rate of ROSC was very high, only a small number of patients survived the overall VV-ECMO treatment course.
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