Assessment of Dietary Sodium Intake Using the Scored Salt Questionnaire in Autosomal Dominant Polycystic Kidney Disease.
Assessment of Dietary Sodium Intake Using the Scored Salt Questionnaire in Autosomal Dominant Polycystic Kidney Disease.
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DOI：
10.3390/nu12113376
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发表时间：
2020-11-02
期刊：
影响因子：
5.9
通讯作者：
Rangan GK
中科院分区：
文献类型：
--
作者：
Wong ATY;Munt A;Allman-Farinelli M;Badve SV;Boudville N;Coolican H;Chandra AN;Coulshed S;Fernando M;Grantham J;Haloob I;Harris DCH;Hawley CM;Holt J;Johnson DW;Kumar K;Lee VW;Lonergan M;Mai J;Rangan A;Roger SD;Saravanabavan S;Sud K;Torres VE;Vilayur E;Zhang JQJ;Rangan GK
膳食钠的过量摄入是减缓常染色体显性遗传性多囊肾病(ADPKD)疾病进展的关键可调节因素。本研究的目的是验证盐分问卷(SSQ；九种富钠食物类型的频率问卷)是识别ADPKD患者高盐摄入量的有效工具的假设。在预防-ADPKD试验的筛查访问期间，使用估计的肾小球滤过率(EGFR)≥30毫升/分钟/1.73m2来评估SSQ在成人ADPKD中的表现。两个样本的平均24小时尿钠排泄量≥为100mmo1/d，定义为高钠摄入量。24小时尿钠排泄量中位数为132 mmol/d(IQR：112~172 mmol/d)(n=75；平均年龄：44.6±11.5岁；女性占53%)，HSI(86.7%)与男性、较高的BMI和收缩压有关(p<；0.05)。SSQ评分(73±23；均值±SD)与24小时尿钠排泄量呈弱相关(r=0.29，p=0.01)。接受操作特征分析显示，预测HSI的最佳临界点为SSQ评分74分(曲线下面积0.79；敏感性61.5%；特异性90.0%；p<；0.01)。用体重指数≥25(n=46)对受试者的SSQ进行评估，提高了敏感性(100%)和特异性(100%)。SSQ得分为≥74(n=41)的消费者对加工肉类/海鲜和添加到烹饪中的调味品的相对摄入量较高(p<；0.05)。总之，SSQ是识别ADPKD患者高食盐摄入量的有效工具，但其价值主张(超过24小时尿钠测量)是它可以为消费者及其医疗保健提供者提供对富钠食物来源的潜在来源的洞察。
The excess intake of dietary sodium is a key modifiable factor for reducing disease progression in autosomal dominant polycystic kidney disease (ADPKD). The aim of this study was to test the hypothesis that the scored salt questionnaire (SSQ; a frequency questionnaire of nine sodium-rich food types) is a valid instrument to identify high dietary salt intake in ADPKD. The performance of the SSQ was evaluated in adults with ADPKD with an estimated glomerular filtration rate (eGFR) ≥ 30 mL/min/1.73 m2 during the screening visit of the PREVENT-ADPKD trial. High dietary sodium intake (HSI) was defined by a mean 24-h urinary sodium excretion ≥ 100 mmol/day from two collections. The median 24-h urine sodium excretion was 132 mmol/day (IQR: 112–172 mmol/d) (n = 75; mean age: 44.6 ± 11.5 years old; 53% female), and HSI (86.7% of total) was associated with male gender and higher BMI and systolic blood pressure (p < 0.05). The SSQ score (73 ± 23; mean ± SD) was weakly correlated with log10 24-h urine sodium excretion (r = 0.29, p = 0.01). Receiving operating characteristic analysis showed that the optimal cut-off point in predicting HSI was an SSQ score of 74 (area under the curve 0.79; sensitivity 61.5%; specificity 90.0%; p < 0.01). The evaluation of the SSQ in participants with a BMI ≥ 25 (n = 46) improved the sensitivity (100%) and the specificity (100%). Consumers with an SSQ score ≥ 74 (n = 41) had higher relative percentage intake of processed meats/seafood and flavourings added to cooking (p < 0.05). In conclusion, the SSQ is a valid tool for identifying high dietary salt intake in ADPKD but its value proposition (over 24-h urinary sodium measurement) is that it may provide consumers and their healthcare providers with insight into the potential origin of sodium-rich food sources.
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影响因子：
3.2
作者：
Mason, Belinda;Ross, Lynda;Kark, Adrian
通讯作者：
Kark, Adrian
影响因子：
2.3
作者：
Jensen, Janni M.;Mose, Frank H.;Pedersen, Erling B.
通讯作者：
Pedersen, Erling B.
影响因子：
4.5
作者：
Grimes CA;Kelley SJ;Stanley S;Bolam B;Webster J;Khokhar D;Nowson CA
通讯作者：
Nowson CA
影响因子：
8.9
作者：
Baker, Phillip;Machado, Priscila;Lawrence, Mark
通讯作者：
Lawrence, Mark
DOI：
10.5334/egems.226
发表时间：
2017-06-12
期刊：
EGEMS (Washington, DC)
影响因子：
--
作者：
Luong, Duc Thanh Anh;Tran, Dinh;Fox, Chester H
通讯作者：
Fox, Chester H