Clearing Your Mind: Mechanisms of Debris Clearance After Cell Death During Neural Development.
Clearing Your Mind: Mechanisms of Debris Clearance After Cell Death During Neural Development.
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DOI：
10.1146/annurev-neuro-110920-022431
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发表时间：
2022-07-08
影响因子：
13.9
通讯作者：
中科院分区：
文献类型：
--
作者：
几十年来，神经发育和细胞发热症一直让科学家们着迷。生物体如何建立一个神经系统，精确地调整为有效的行为和生存，以及它如何同时管理恒定的体细胞周转是复杂的问题，导致了不同的研究领域。虽然神经发育需要细胞的过度生产，随后修剪回来，很少有研究结合这些领域来阐明通过细胞清除的透镜驱动神经系统发育的细胞和分子机制。在这篇评论中，我们讨论这些领域，以突出未来协同作用的令人兴奋的领域。我们首先从过度生产和随后的完善的角度回顾神经发育，然后讨论谁清除这些发育碎片和控制这些事件的机制。最后，我们将讨论如何将神经发育和红细胞增多症更慎重地结合起来，重新构建我们对内稳态和疾病的理解，并讨论未来的研究领域。
Neurodevelopment and efferocytosis have fascinated scientists for decades. How an organism builds a nervous system that is precisely tuned for efficient behaviors and survival and how it simultaneously manages constant somatic cell turnover are complex questions that have resulted in distinct fields of study. Although neurodevelopment requires the overproduction of cells that are subsequently pruned back, very few studies marry these fields to elucidate the cellular and molecular mechanisms that drive nervous system development through the lens of cell clearance. In this review, we discuss these fields to highlight exciting areas of future synergy. We first review neurodevelopment from the perspective of overproduction and subsequent refinement and then discuss who clears this developmental debris and the mechanisms that control these events. We then end with how a more deliberate merger of neurodevelopment and efferocytosis could reframe our understanding of homeostasis and disease and discuss areas of future study.
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影响因子：
16.2
作者：
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通讯作者：
Greenberg ME
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作者：
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