Melanesian mtDNA complexity.
Melanesian mtDNA complexity.
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DOI：
10.1371/journal.pone.0000248
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发表时间：
2007-02-28
期刊：
影响因子：
3.7
通讯作者：
Merriwether DA
中科院分区：
文献类型：
--
作者：
Friedlaender JS;Friedlaender FR;Hodgson JA;Stoltz M;Koki G;Horvat G;Zhadanov S;Schurr TG;Merriwether DA
美拉尼西亚人口以其多样性而闻名，但很难掌握这种变化的模式或其潜在的动态。利用来自32个人群的1,223个线粒体DNA （mtDNA）序列，研究人员发现，群体间的变异是由岛屿、岛屿大小和语言关系构成的。在最大的岛屿上，更孤立的内陆巴布亚语群体具有最大的差异，而海岸居民的多样性则要少得多（与此同时，在最孤立的群体中，群体内的单倍型多样性较少）。沿海和内陆群体在有效人口规模和婚姻迁移率方面的持续差异可能导致了这些差异。我们还添加了16个完整的序列到美拉尼西亚mtDNA系统发育中。我们在特定的岛屿上确定了许多单倍群和古代分支的可能起源，指出了近大洋洲和澳大利亚之间的一些古代mtDNA连接，并显示了东南亚岛屿/台湾和美拉尼西亚岛与e单倍群分支之间的全新世连接。基于编码区域同义转换的合并估计表明，该地区在距今约30-50,000年（YBP）之前就有了最初的定居和扩张。第二次重要扩张来自东南亚岛屿/台湾，时间间隔为~ 3500 - 8000 YBP。然而，在分子测年中，有一些重要的变异成分被忽视了，而且南岛人祖先（母系）对该地区影响的具体性质仍未得到解决。
Melanesian populations are known for their diversity, but it has been hard to grasp the pattern of the variation or its underlying dynamic. Using 1,223 mitochondrial DNA (mtDNA) sequences from hypervariable regions 1 and 2 (HVR1 and HVR2) from 32 populations, we found the among-group variation is structured by island, island size, and also by language affiliation. The more isolated inland Papuan-speaking groups on the largest islands have the greatest distinctions, while shore dwelling populations are considerably less diverse (at the same time, within-group haplotype diversity is less in the most isolated groups). Persistent differences between shore and inland groups in effective population sizes and marital migration rates probably cause these differences. We also add 16 whole sequences to the Melanesian mtDNA phylogenies. We identify the likely origins of a number of the haplogroups and ancient branches in specific islands, point to some ancient mtDNA connections between Near Oceania and Australia, and show additional Holocene connections between Island Southeast Asia/Taiwan and Island Melanesia with branches of haplogroup E. Coalescence estimates based on synonymous transitions in the coding region suggest an initial settlement and expansion in the region at ∼30–50,000 years before present (YBP), and a second important expansion from Island Southeast Asia/Taiwan during the interval ∼3,500–8,000 YBP. However, there are some important variance components in molecular dating that have been overlooked, and the specific nature of ancestral (maternal) Austronesian influence in this region remains unresolved.
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影响因子：
0.9
作者：
Dunn, M;Reesink, G;Terrill, A
通讯作者：
Terrill, A
影响因子：
10.7
作者：
Friedlaender, J;Schurr, T;Merriwether, DA
通讯作者：
Merriwether, DA
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Merriwether, DA
影响因子：
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作者：
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通讯作者：
Cox, MP