Genetic variation in proinflammatory cytokines IL6, IL6R, TNF-region, and TNFRSF1A and risk of breast cancer.
Genetic variation in proinflammatory cytokines IL6, IL6R, TNF-region, and TNFRSF1A and risk of breast cancer.
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DOI：
10.1007/s10549-011-1520-4
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发表时间：
2011-10
影响因子：
3.8
通讯作者：
Malone, Kathleen E.
中科院分区：
文献类型：
--
作者：
Madeleine, Margaret M.;Johnson, Lisa G.;Malkki, Mari;Resler, Alexa J.;Petersdorf, Effie W.;McKnight, Barbara;Malone, Kathleen E.
促炎细胞因子与年龄相关的疾病有关，包括关节炎和心脏病。白介素6和肿瘤坏死因子在老年女性的雌激素调节中也起着关键作用。我们探讨了IL-6和肿瘤坏死因子基因的变异是否会影响不同年龄组的乳腺癌风险：44岁(228例病例和271例对照)、45岁(426例病例和396例对照)和65岁以上(228例病例和239例对照)。样本取自在西雅图进行的以人群为基础的病例对照研究。计算年龄调整的优势比(OR)以评估与IL6、IL6R、TNF和TNFRSF1A基因变异相关的风险。在年龄最大的人群中，IL6rs2069861的一个或多个C>；T等位基因显著增加了患乳腺癌的风险(OR 1.8，95%可信区间1.1-2.9)，但合并数据中的任何IL6或IL6R变异都没有增加乳腺癌的总体风险。在45-年龄的女性中，携带UTR5‘侧翼SNP LTA rs2009658 C>；G等位基因(OR1.5，95%CI 1.1-1.9)和非同源编码SNP TNFRSF1A rs767455 T>；C等位基因(OR 1.3，95%CI 1.1-1.6)的女性患乳腺癌的风险显著增加；这两个变异体在合并数据中也显著增加(OR1.3，95%CI 1.1-1.5和OR 1.2，95%CI 1.1-1.4)。这项研究支持IL6基因变异与老年女性乳腺癌之间的适度关联，以及与肿瘤坏死因子相关的变异与中年女性乳腺癌之间的适度关联。在其他研究中对这些基因进行进一步评估是有必要的。
Proinflammatory cytokines are associated with age-related diseases including arthritis and heart disease. IL6 and TNF also play key roles in estrogen modulation in older women. We explored whether variation in IL6 and TNF genes influenced the risk of breast cancer in samples that differed by age group: <44 years (228 cases and 271 controls), 45–64 years (426 cases and 396 controls), and 65+ years (228 cases and 239 controls). Samples were drawn from population-based case–control studies conducted in Seattle. Age-adjusted odds ratios (ORs) were calculated to evaluate the risk associated with variants in IL6, IL6R, TNF, and TNFRSF1A. There was a significantly increased risk of breast cancer associated with one or more C>T alleles at IL6 rs2069861 among subjects in the oldest age group (OR 1.8, 95% CI 1.1–2.9), but no overall increased risk of breast cancer associated with any IL6 or IL6R variants in the combined data. There were significantly elevated risks of breast cancer among women 45–64 years old associated with a UTR 5′ flanking SNP LTA rs2009658 C>G allele (OR 1.5, 95% CI 1.1–1.9) and a nonsynonomous coding SNP TNFRSF1A rs767455 T>C allele (OR 1.3, 95% CI 1.1–1.6); these two variants were also elevated in the combined data (OR 1.3, 95% CI 1.1–1.5 and OR 1.2, 95% CI 1.1–1.4, respectively). This study supports a modest association between a variant in IL6 and breast cancer among older women and TNF-related variants and breast cancer among middle-aged women. Further evaluation of these genes in other studies is warranted.
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影响因子：
5.3
作者：
Gaudet, Mia M.;Egan, Kathleen M.;Garcia-Closas, Montserrat
通讯作者：
Garcia-Closas, Montserrat
影响因子：
11.5
作者：
Hefler, LA;Grimm, C;Zeillinger, R
通讯作者：
Zeillinger, R
影响因子：
50.3
作者：
Allinen, M;Beroukhim, R;Polyak, K
通讯作者：
Polyak, K
影响因子：
6.4
作者：
Li, CI;Malone, KE;Daling, JR
通讯作者：
Daling, JR
五种多态性和乳腺癌风险：乳腺癌协会联盟的结果。
DOI：
10.1158/1055-9965.epi-08-0745
发表时间：
2009-05
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Gaudet MM;Milne RL;Cox A;Camp NJ;Goode EL;Humphreys MK;Dunning AM;Morrison J;Giles GG;Severi G;Baglietto L;English DR;Couch FJ;Olson JE;Wang X;Chang-Claude J;Flesch-Janys D;Abbas S;Salazar R;Mannermaa A;Kataja V;Kosma VM;Lindblom A;Margolin S;Heikkinen T;Kämpjärvi K;Aaltonen K;Nevanlinna H;Bogdanova N;Coinac I;Schürmann P;Dörk T;Bartram CR;Schmutzler RK;Tchatchou S;Burwinkel B;Brauch H;Torres D;Hamann U;Justenhoven C;Ribas G;Arias JI;Benitez J;Bojesen SE;Nordestgaard BG;Flyger HL;Peto J;Fletcher O;Johnson N;Dos Santos Silva I;Fasching PA;Beckmann MW;Strick R;Ekici AB;Broeks A;Schmidt MK;van Leeuwen FE;Van't Veer LJ;Southey MC;Hopper JL;Apicella C;Haiman CA;Henderson BE;Le Marchand L;Kolonel LN;Kristensen V;Grenaker Alnaes G;Hunter DJ;Kraft P;Cox DG;Hankinson SE;Seynaeve C;Vreeswijk MP;Tollenaar RA;Devilee P;Chanock S;Lissowska J;Brinton L;Peplonska B;Czene K;Hall P;Li Y;Liu J;Balasubramanian S;Rafii S;Reed MW;Pooley KA;Conroy D;Baynes C;Kang D;Yoo KY;Noh DY;Ahn SH;Shen CY;Wang HC;Yu JC;Wu PE;Anton-Culver H;Ziogoas A;Egan K;Newcomb P;Titus-Ernstoff L;Trentham Dietz A;Sigurdson AJ;Alexander BH;Bhatti P;Allen-Brady K;Cannon-Albright LA;Wong J;Australian Ovarian Cancer Study Group;Chenevix-Trench G;Spurdle AB;Beesley J;Pharoah PD;Easton DF;Garcia-Closas M;Breast Cancer Association Consortium
通讯作者：
Breast Cancer Association Consortium