Long-term outcomes of endoscopic submucosal dissection for superficial esophageal squamous cell carcinoma in Taiwan.
Long-term outcomes of endoscopic submucosal dissection for superficial esophageal squamous cell carcinoma in Taiwan.
复制标题
DOI：
10.1186/s12876-021-01888-1
复制
发表时间：
2021-08-03
影响因子：
2.4
通讯作者：
Lee CT
中科院分区：
文献类型：
--
作者：
Hsu MH;Wang WL;Chen TH;Tai CM;Wang HP;Lee CT
Endoscopic submucosal dissection (ESD) is gradually turning into the standard treatment for superficial esophageal squamous cell carcinoma (SESCC), however, the long-term outcomes have hardly ever been reported outside Japan. We consecutively recruited patients with SESCC who had received ESD treatment at E-Da Hospital. The demographics, pathological characteristics, and Lugol staining background pattern (type A or B: none or < 10 small Lugol-voiding lesions [LVLs]; type C or D: > 10 small or multiform LVLs) were collected, and then correlated to outcomes and survival. Total of 229 lesions were enrolled and the mean lesion size was 3.28 ± 1.69 (range 1–10) cm. 72% of the lesions had a type C-D Lugol staining background pattern. After ESD, the en bloc and R0 resection rates were 93.9% and 83.5%, respectively. Forty-nine subjects developed complications, including six (2.6%) with major bleeding, two (0.9%) with perforation, and 41 (17.9%) with strictures. Pathological staging showed that 19 cases had deep submucosal cancer invasion and subsequently received adjuvant therapies. During a mean follow-up period of 52.6 (range 3–146) months, 41 patients developed metachronous recurrence. The patients with a type C-D Lugol staining background pattern were associated with a higher risk of recurrence than those with few LVLs (log-rank P = 0.019). The 10-year survival rate was more than 90%, and only eight patients died of ESCC. ESD has excellent long-term outcomes but a high risk of metachronous recurrence. The Lugol staining pattern over the background mucosa could offer the risk stratification of metachronous recurrence.
登录
查看更多内容
影响因子：
2.9
作者：
Fukuhara, Tatsuma;Hiyama, Toru;Chayama, Kazuaki
通讯作者：
Chayama, Kazuaki
影响因子：
7.7
作者：
Muto, M;Hironaka, S;Yoshida, S
通讯作者：
Yoshida, S
影响因子：
2.4
作者：
Kuwano, Hiroyuki;Nishimura, Yasumasa;Oyama, Tsuneo;Kato, Hiroyuki;Kitagawa, Yuko;Kusano, Motoyasu;Shimada, Hideo;Takiuchi, Hiroya;Toh, Yasushi;Doki, Yuichiro;Naomoto, Yoshio;Matsubara, Hisahiro;Miyazaki, Tatsuya;Muto, Manabu;Yanagisawa, Akio
通讯作者：
Yanagisawa, Akio
DOI：
10.1111/j.1349-7006.2002.tb02173.x
发表时间：
2002-03
期刊：
Japanese journal of cancer research : Gann
影响因子：
--
作者：
Nakajima Y;Nagai K;Miyake S;Ohashi K;Kawano T;Iwai T
通讯作者：
Iwai T
影响因子：
2.6
作者：
Mizuta, H.;Nishimori, I.;Onishi, S.
通讯作者：
Onishi, S.