Efficacy, safety and complications of autologous fat grafting to the eyelids and periorbital area: A systematic review and meta-analysis.
Efficacy, safety and complications of autologous fat grafting to the eyelids and periorbital area: A systematic review and meta-analysis.
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眼睑和眶周区域自体脂肪移植的功效、安全性和并发症：系统评价和荟萃分析
DOI：
10.1371/journal.pone.0248505
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Zhang W
中科院分区：
文献类型：
--
作者：
Yang F;Ji Z;Peng L;Fu T;Liu K;Dou W;Li J;Li Y;Long Y;Zhang W
背景近年来，自体脂肪移植（AFG），也称为脂肪转移或脂肪填充，已被广泛用于眶周年轻化和缺损矫正，但其有效性和安全性的证据仍然缺乏。此外，相对于眶周区域，它总是面部老化现象最早出现的区域。因此，需要进行系统综述和荟萃分析，以评估该技术的有效性和安全性。方法2020年11月20日，根据PRISMA指南，在PubMed、Embase和科克伦图书馆数据库中进行文献检索，以识别所有相关文章。然后，进行数据提取和标准化过程，以评估所有结局数据。最后，使用随机效应回归模型和综合荟萃分析软件对数据进行评估。结果共纳入39篇研究，包括3个队列，36个病例系列，共4046例病例。Meta分析显示满意率较高，为90.9%（95%CI，86.4%-94.0%）。4046例接受AFG的患者中常见的并发症为水肿、球结膜水肿和轮廓不规则，总体并发症发生率为7.9%（95%CI，4.8%-12.8%）。结论AFG用于眼睑和眶周区域年轻化的系统评价和荟萃分析显示，AFG提供了较高的满意率，且未导致严重并发症。因此，AFG可以安全地用于眶周年轻化和重建。
Background In recent years, autologous fat grafting (AFG), also known as fat transfer or lipofilling, has been widely performed for periorbital rejuvenation and defect correction, although the evidence regarding its efficacy and safety is still lacking. Besides, with respect to the periorbital region, it is invariably the earliest appearance area of the facial aging phenomenon. Therefore, a systematic review and meta-analysis is needed to evaluate the efficacy and safety of this technique. Methods A literature search was performed in PubMed, Embase, and the Cochrane library databases on November 20, 2020, adhering to the PRISMA guidelines, to identify all relevant articles. Then, a data extraction and standardization process was performed to assess all outcome data. Ultimately, the data were assessed using a random effects regression model with comprehensive meta-analysis software. Results Thirty-nine studies consisting of 3 cohorts and 36 case series with a total of 4046 cases were included. Meta-analysis revealed a relatively high satisfaction rate of 90.9% (95% CI, 86.4%–94.0%). Frequent complications in 4046 patients receiving AFG were edema, chemosis, and contour irregularity, with an overall complication rate of 7.9% (95% CI, 4.8%–12.8%). Conclusion This systematic review and meta-analysis showed that AFG for rejuvenation of eyelids and periorbital area provided a high satisfaction rate and did not result in severe complications. Therefore, AFG might be performed safely for periorbital rejuvenation and reconstruction.
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