Chemical signal amplification in two-dimensional paper networks.

Chemical signal amplification in two-dimensional paper networks.
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DOI:
10.1016/j.snb.2010.06.024
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发表时间:
2010-08-06
影响因子:
8.4
通讯作者:
Yager, Paul
Yager, Paul
中科院分区:
化学1区
文献类型:
--
作者:
Fu, Elain;Kauffman, Peter;Lutz, Barry;Yager, Paul

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二维纸网络(2DPN)具有很大的潜力,可以扩展基于纸的化学和生物化学诊断的实用性,其成本和易用性与传统的横向流动条相当。2DPN能够通过单个用户激活步骤将多种试剂自动顺序递送到检测区域,因此具有扩展廉价纸基测定的处理能力的潜力,其使用方便性与常规侧流测试相当。在本通信中,我们使用简单的3入口2DPN使用金增强溶液对胶体金标记进行信号放大,从而证明了2DPN执行可以提高检测限的过程的能力。
Two-dimensional paper networks (2DPNs) hold great potential for extending the utility of paper-based chemical and biochemical diagnostics at a cost and ease-of-use that is comparable to conventional lateral flow strips. 2DPNs enable the automated sequential delivery of multiple reagents to a detection region with a single user activation step, and therefore have the potential to extend the processing capabilities of inexpensive paper-based assays with comparable ease of use to conventional lateral flow tests. In this communication, we used a simple 3 inlet 2DPN to perform signal amplification of a colloidal gold label using a gold enhancement solution, thus demonstrating the capability of 2DPNs to perform processes that can improve limits of detection.
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