Optical treatment of strabismic and combined strabismic-anisometropic amblyopia.
Optical treatment of strabismic and combined strabismic-anisometropic amblyopia.
复制标题
DOI：
10.1016/j.ophtha.2011.06.043
复制
发表时间：
2012-01
期刊：
影响因子：
13.7
通讯作者：
Suh DW
中科院分区：
文献类型：
--
作者：
Writing Committee for the Pediatric Eye Disease Investigator Group;Cotter SA;Foster NC;Holmes JM;Melia BM;Wallace DK;Repka MX;Tamkins SM;Kraker RT;Beck RW;Hoover DL;Crouch ER 3rd;Miller AM;Morse CL;Suh DW
确定斜视和斜视-屈光参差（联合机制）弱视儿童单独接受光学矫正治疗的视力改善情况，并探讨与改善相关的因素。前瞻性多中心队列研究，146名3至<7岁儿童，既往未经治疗的斜视性弱视（N=52）或联合机制弱视（N=94）。提供光学治疗，即在基线访视时首次佩戴眼镜（基于睫状肌麻痹屈光的处方）。使用弱视治疗研究HOTV ®视力方案在基线和此后每9周测量戴眼镜的视力，直到视力没有进一步改善。在每次访视时评估眼部对准。基线后18周的视力。总体而言，弱视眼视力平均改善2.6行（95%置信区间：2.3 - 3.0），75%的儿童改善≥2行，54%改善≥3行。弱视的解决发生在32%（95%置信区间：24%至41%）的儿童。斜视性弱视的治疗效果大于联合机制弱视（3.2线对2.3线，调整后P=0.003）。无论眼睛对准是否改善，视力都得到改善。对于大多数3至<7岁的儿童，斜视和联合机制弱视的单独光学治疗可导致弱视眼视力的临床有意义的改善，至少在四分之一内消退而无需额外治疗。在开始其他治疗之前，应考虑将屈光矫正作为斜视或联合机制弱视儿童的唯一初始治疗。
To determine visual acuity improvement in children with strabismic and combined strabismic-anisometropic (combined-mechanism) amblyopia treated with optical correction alone and to explore factors associated with improvement. Prospective multi-center cohort study 146 children 3 to <7 years old with previously untreated strabismic amblyopia (N=52) or combined-mechanism amblyopia (N=94). Optical treatment was provided as spectacles (prescription based on a cycloplegic refraction) that were worn for the first time at the baseline visit. Visual acuity with spectacles was measured using the Amblyopia Treatment Study HOTV© visual acuity protocol at baseline and every 9 weeks thereafter until no further improvement in visual acuity. Ocular alignment was assessed at each visit. Visual acuity 18 weeks after baseline. Overall, amblyopic eye visual acuity improved a mean of 2.6 lines (95% confidence interval: 2.3 to 3.0), with 75% of children improving ≥2 lines and 54% improving ≥3 lines. Resolution of amblyopia occurred in 32% (95% confidence interval: 24% to 41%) of the children. The treatment effect was greater for strabismic amblyopia than for combined-mechanism amblyopia (3.2 versus 2.3 lines, adjusted P=0.003). Visual acuity improved regardless of whether eye alignment improved. Optical treatment alone of strabismic and combined-mechanism amblyopia results in clinically meaningful improvement in amblyopic eye visual acuity for most 3 to <7-year-old children, resolving in at least one quarter without the need for additional treatment. Consideration should be given to prescribing refractive correction as the sole initial treatment for children with strabismic or combined-mechanism amblyopia before initiating other therapies.
登录
查看更多内容
影响因子：
13.7
作者：
Agervi, Pia;Kugelberg, Ulla;Zetterstroem, Charlotta
通讯作者：
Zetterstroem, Charlotta
影响因子：
--
作者：
Cotter, Susan A.;Weakley, David R., Jr.;Wheeler, David T.
通讯作者：
Wheeler, David T.
影响因子：
1.4
作者：
Thibos, LN;Wheeler, W;Horner, D
通讯作者：
Horner, D
影响因子：
1.6
作者：
Leske, DA;Holmes, JM
通讯作者：
Holmes, JM
影响因子：
2.9
作者：
Moseley, MJ;Neufeld, M;Fielder, A
通讯作者：
Fielder, A