The significance of virulence factors in Helicobacter pylori.
The significance of virulence factors in Helicobacter pylori.
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DOI：
10.1111/1751-2980.12054
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发表时间：
2013-07
影响因子：
3.5
通讯作者：
Yamaoka Y
中科院分区：
文献类型：
--
作者：
Shiota S;Suzuki R;Yamaoka Y
幽门螺杆菌感染与多种胃十二指肠疾病有关；然而，这些患者中只有一小部分会患上相关疾病。尽管非洲和南亚的幽门螺旋杆菌感染率很高，但这些地区的胃癌发病率远低于其他国家。东亚地区胃癌的发病率自北向南呈下降趋势。除了宿主和环境因素外，存在不同类型的幽门螺杆菌毒力因素可以解释这种病理上的地理差异，至少部分如此。幽门螺杆菌的毒力因子，如cagA、vacA、dupA、iceA、oipA和babA，已被证明是严重临床结局的预测因子。有趣的是，荟萃分析显示，与胃炎相比，CagA血清阳性与胃癌相关，即使在东亚国家，几乎所有菌株都具有CagA。meta分析也证实了vacA、dupA和iceA的显著性。然而，由于幽门螺杆菌由大约1600个基因组成，因此仍然有可能存在其他重要的致病基因。尽管我们对幽门螺杆菌相关疾病的发展的了解有所进展，但需要进一步的工作来阐明幽门螺杆菌毒力因素的作用。
Helicobacter pylori (H. pylori) infection is linked to various gastroduodenal diseases; however, only a small fraction of these patients develop associated diseases. Despite the high prevalence of H. pylori infection in Africa and South Asia, the incidence of gastric cancer in these areas is much lower than those in other countries. The incidence of gastric cancer tends to decrease from north to south in East Asia. Such geographic differences in the pathology can be explained, at least in part, by the presence of different types of H. pylori virulence factors in addition to the host and environmental factors. Virulence factors of H. pylori, such as cagA, vacA, dupA, iceA, oipA and babA, have been demonstrated to be predictors of severe clinical outcomes. Interestingly, meta-analysis showed that CagA seropositivity was associated with gastric cancer compared with gastritis even in East Asian countries where almost of the strains possessing cagA. Meta-analysis also confirmed the significance of vacA, dupA and iceA. However, there remains the possibility that additional important pathogenic genes can be existed because H. pylori consists of approximately 1 600 genes. Despite advances in our understanding of the development of H. pylori-related diseases, further work is required to clarify the roles of H. pylori virulence factors.
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影响因子：
24.5
作者：
de Sablet T;Piazuelo MB;Shaffer CL;Schneider BG;Asim M;Chaturvedi R;Bravo LE;Sicinschi LA;Delgado AG;Mera RM;Israel DA;Romero-Gallo J;Peek RM Jr;Cover TL;Correa P;Wilson KT
通讯作者：
Wilson KT
影响因子：
4.1
作者：
Matsuo Y;Shiota S;Matsunari O;Suzuki R;Watada M;Binh TT;Kinjo N;Kinjo F;Yamaoka Y
通讯作者：
Yamaoka Y
影响因子：
6.4
作者：
Hussein, Nawfal R.;Argent, Richard H.;Atherton, John C.
通讯作者：
Atherton, John C.
影响因子：
9.4
作者：
Ito, Y;Azuma, T;Kuriyama, M
通讯作者：
Kuriyama, M
影响因子：
9.4
作者：
Jones, Kathleen R.;Jang, Sungil;Cha, Jeong-Heon
通讯作者：
Cha, Jeong-Heon