Applying time series analyses on continuous accelerometry data-A clinical example in older adults with and without cognitive impairment.
Applying time series analyses on continuous accelerometry data-A clinical example in older adults with and without cognitive impairment.
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DOI：
10.1371/journal.pone.0251544
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Flöel A
中科院分区：
文献类型：
--
作者：
Rackoll T;Neumann K;Passmann S;Grittner U;Külzow N;Ladenbauer J;Flöel A
许多报告加速度测量数据的临床研究使用总和评分测量，例如中度至剧烈活动所花费的时间百分比，其不能提供对24小时内活动模式差异的洞察，因此不能充分描述昼夜活动模式。在这里，我们提出了一种改进的功能数据分析方法，从加速度计数据中建模活动模式和昼夜节律。作为一个用例，我们展示了它在轻度认知障碍（MCI）患者和年龄匹配的健康老年志愿者（HOV）中的应用。本分析合并了两项研究的数据。在基线认知评估之后，为参与者提供连续七天的加速度计。标量回归函数（FoSR）方法被用来分析24小时加速度计数据。48例HOV（平均年龄65 SD 6岁）和18例MCI患者（平均年龄70，SD 8岁）的信息可用于本分析。MCI患者在早晨的活动量略低，（上午6：05的最小相对活性：-41.3%，95%CI-64.7至-2.5%，p = 0.031）和晚上（在21：40 am时的最小相对活性：-48.4%，95%CI-68.5至15.4%，p = 0.001）。使用FoSR的新方法，我们发现MCI患者的活动水平低于HOV的时间范围，如果使用活动量的总和评分，则不明显，这可能表明神经退行性疾病的昼夜节律变化可以使用易于管理的加速度计检测到。夜间睡眠期间脑刺激对轻度认知障碍患者记忆巩固的影响，ClinicalTrial.gov标识符：NCT 01782391。白天小睡期间脑刺激对轻度认知障碍患者记忆巩固的影响，ClinicalTrial.gov标识符：NCT 01782365。
Many clinical studies reporting accelerometry data use sum score measures such as percentage of time spent in moderate to vigorous activity which do not provide insight into differences in activity patterns over 24 hours, and thus do not adequately depict circadian activity patterns. Here, we present an improved functional data analysis approach to model activity patterns and circadian rhythms from accelerometer data. As a use case, we demonstrated its application in patients with mild cognitive impairment (MCI) and age-matched healthy older volunteers (HOV). Data of two studies were pooled for this analysis. Following baseline cognitive assessment participants were provided with accelerometers for seven consecutive days. A function on scalar regression (FoSR) approach was used to analyze 24 hours accelerometer data. Information on 48 HOV (mean age 65 SD 6 years) and 18 patients with MCI (mean age 70, SD 8 years) were available for this analysis. MCI patients displayed slightly lower activity in the morning hours (minimum relative activity at 6:05 am: -41.3%, 95% CI -64.7 to -2.5%, p = 0.031) and in the evening (minimum relative activity at 21:40 am: -48.4%, 95% CI -68.5 to 15.4%, p = 0.001) as compared to HOV after adjusting for age and sex. Using a novel approach of FoSR, we found timeframes with lower activity levels in MCI patients compared to HOV which were not evident if sum scores of amount of activity were used, possibly indicating that changes in circadian rhythmicity in neurodegenerative disease are detectable using easy-to-administer accelerometry. Effects of Brain Stimulation During Nocturnal Sleep on Memory Consolidation in Patients With Mild Cognitive Impairments, ClinicalTrial.gov identifier: NCT01782391. Effects of Brain Stimulation During a Daytime Nap on Memory Consolidation in Patients With Mild Cognitive Impairment, ClinicalTrial.gov identifier: NCT01782365.
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影响因子：
2
作者：
Crainiceanu, Ciprian M.;Staicu, Ana-Maria;Ray, Shubankar;Punjabi, Naresh
通讯作者：
Punjabi, Naresh
健康老年人的昼夜节律、睡眠和认知障碍之间的关联：一项活动记录研究
影响因子：
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作者：
Cochrane, Andy;Robertson, Ian H.;Coogan, Andrew N.
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3.5
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影响因子：
5.6
作者：
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通讯作者：
Buxton, Orfeu M.
影响因子：
2.1
作者：
Oyegbami, Olaide;Collins, Hilary M.;Moran, Paula M.
通讯作者：
Moran, Paula M.