Longitudinal follow-up of IgG anti-nucleocapsid antibodies in SARS-CoV-2 infected patients up to eight months after infection.
Longitudinal follow-up of IgG anti-nucleocapsid antibodies in SARS-CoV-2 infected patients up to eight months after infection.
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DOI：
10.1016/j.jcv.2021.104765
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Vermeersch P
中科院分区：
文献类型：
--
作者：
Van Elslande J;Oyaert M;Ailliet S;Van Ranst M;Lorent N;Vande Weygaerde Y;André E;Lagrou K;Vandendriessche S;Vermeersch P
大多数SARS-CoV-2感染患者在症状发作后2-3周内产生IgG抗体。抗体水平已被证明在感染后的头几个月逐渐下降，但在六个月或更晚的数据很少。采用来自比利时2所大学医院的236例PCR证实的SARS-CoV-2感染患者的652份样本进行了回顾性多中心研究。如果至少有两份样本可用（范围2-7份样本），则纳入患者;包括在首次阳性PCR后30天或之后采集的至少一份样本（范围0-240天）。在这236例患者中，19.1%被归类为轻度/无症状（轻度），80.9%被归类为中度至危重（重度）。使用Abbott Architect免疫测定法测量IgG抗核衣壳抗体（抗N）。22.2%的轻度和2.6%的重度COVID-19病例从未发生血清转化（p < 0.001）。在PCR后0-59天血清转化的轻度患者中，分别有18.8%、40.0%和61.1%的患者在PCR后60-119天、120-179天和180-240天的时间窗内血清阴性。在重症患者中，这些数字分别为1.9%，10.8%和29.4%（p < 0.05）。在每个60天窗口中，与轻度患者相比，重度患者的抗体水平显著更高（各自p < 0.001）。PCR后2个月至8个月，SARS-CoV-2抗N IgG抗体水平稳步下降。在严重的COVID-19患者中，70. 6%在感染后长达8个月仍保持阳性。轻度SARS-CoV-2感染患者的抗体水平显著较低，61.1%在首次PCR阳性后6个月内变为血清阴性。
Most SARS-CoV-2 infected patients develop IgG antibodies within 2–3 weeks after symptom onset. Antibody levels have been shown to gradually decrease in the first months after infection, but few data are available at six months or later. A retrospective multi-center study was performed using 652 samples of 236 PCR-confirmed SARS-CoV-2 infected patients from 2 Belgian University hospitals. Patients were included if at least two samples were available (range 2–7 samples); including at least one sample collected 30 days or later after first positive PCR (range 0–240 days). Of those 236 patients, 19.1 % were classified as mild/asymptomatic (mild) and 80.9 % as moderate to critical (severe). IgG anti-nucleocapsid antibodies (anti-N) were measured using the Abbott Architect immunoassay. 22.2 % of mild and 2.6 % of severe COVID-19 cases never seroconverted (p < 0.001). Of the mild patients who seroconverted 0–59 days after PCR; 18.8 %, 40.0 % and 61.1 % were seronegative in the windows 60–119 days, 120–179 days and 180–240 days after PCR, respectively. In severe patients, these numbers were 1.9 %, 10.8 % and 29.4 % respectively (p < 0.05 each). Antibody levels were significantly higher in severe patients compared to mild patients in each 60 day window (p < 0.001 each). SARS-CoV-2 anti-N IgG antibody levels steadily decreased after 2 months up to 8 months post PCR. Of severe COVID-19 patients, 70.6 % remained positive up to eight months after infection. Antibody levels were significantly lower in mild SARS-CoV-2 infected patients and 61.1 % became seronegative within 6 months after the first positive PCR.
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五个可获得五种可获得SARS-COV-2抗体并鉴定具有高中和滴度的个体的抗体的比较性能。
影响因子：
9.4
作者：
Patel EU;Bloch EM;Clarke W;Hsieh YH;Boon D;Eby Y;Fernandez RE;Baker OR;Keruly M;Kirby CS;Klock E;Littlefield K;Miller J;Schmidt HA;Sullivan P;Piwowar-Manning E;Shrestha R;Redd AD;Rothman RE;Sullivan D;Shoham S;Casadevall A;Quinn TC;Pekosz A;Tobian AAR;Laeyendecker O
通讯作者：
Laeyendecker O
DOI：
10.1056/nejmoa2034545
发表时间：
2021-02-11
期刊：
The New England journal of medicine
影响因子：
--
作者：
Lumley SF;O'Donnell D;Stoesser NE;Matthews PC;Howarth A;Hatch SB;Marsden BD;Cox S;James T;Warren F;Peck LJ;Ritter TG;de Toledo Z;Warren L;Axten D;Cornall RJ;Jones EY;Stuart DI;Screaton G;Ebner D;Hoosdally S;Chand M;Crook DW;O'Donnell AM;Conlon CP;Pouwels KB;Walker AS;Peto TEA;Hopkins S;Walker TM;Jeffery K;Eyre DW;Oxford University Hospitals Staff Testing Group
通讯作者：
Oxford University Hospitals Staff Testing Group
影响因子：
11.1
作者：
Padoan A;Bonfante F;Pagliari M;Bortolami A;Negrini D;Zuin S;Bozzato D;Cosma C;Sciacovelli L;Plebani M
通讯作者：
Plebani M
使用Abbott Architect的有症状的Covid-19患者中IgM和IgG体液反应的纵向表征。
DOI：
10.1016/j.jcv.2020.104663
发表时间：
2020-12
期刊：
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
影响因子：
--
作者：
Maine GN;Lao KM;Krishnan SM;Afolayan-Oloye O;Fatemi S;Kumar S;VanHorn L;Hurand A;Sykes E;Sun Q
通讯作者：
Sun Q
影响因子：
56.9
作者：
Yu, Jingyou;Tostanoski, Lisa H.;Barouch, Dan H.
通讯作者：
Barouch, Dan H.