Mesenchymal Stem Cells Transplantation in Intracerebral Hemorrhage: Application and Challenges.
Mesenchymal Stem Cells Transplantation in Intracerebral Hemorrhage: Application and Challenges.
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DOI：
10.3389/fncel.2021.653367
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发表时间：
2021
影响因子：
5.3
通讯作者：
Wang BC
中科院分区：
文献类型：
--
作者：
Gong YH;Hao SL;Wang BC
脑出血（ICH）是世界范围内死亡和长期残疾的主要原因之一。间充质干细胞（MSC）疗法已证明可改善ICH诱导的神经元缺陷的治疗效果，并通过神经发生、血管生成、抗炎和抗凋亡机制增强啮齿动物ICH模型中的神经网络重建和神经功能恢复。然而，许多与移植的MSC在ICH后的存活、分化和安全性相关的关键问题仍有待解决，这阻碍了MSC治疗的临床转化。本文综述了近年来骨髓间充质干细胞移植治疗脑出血的研究进展，并对骨髓间充质干细胞移植治疗脑出血面临的挑战进行了总结。并提出了改善MSC移植效果的有效策略。
Intracerebral hemorrhage (ICH) is one of the leading causes of death and long-term disability worldwide. Mesenchymal stem cell (MSC) therapies have demonstrated improved outcomes for treating ICH-induced neuronal defects, and the neural network reconstruction and neurological function recovery were enhanced in rodent ICH models through the mechanisms of neurogenesis, angiogenesis, anti-inflammation, and anti-apoptosis. However, many key issues associated with the survival, differentiation, and safety of grafted MSCs after ICH remain to be resolved, which hinder the clinical translation of MSC therapy. Herein, we reviewed an overview of the research status of MSC transplantation after ICH in different species including rodents, swine, monkey, and human, and the challenges for MSC-mediated ICH recovery from pathological microenvironment have been summarized. Furthermore, some efficient strategies for the outcome improvement of MSC transplantation were proposed.
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