Stem Cell Therapy: A Promising Therapeutic Method for Intracerebral Hemorrhage.
Stem Cell Therapy: A Promising Therapeutic Method for Intracerebral Hemorrhage.
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干细胞疗法：一种有前景的脑出血治疗方法
DOI：
10.1177/0963689718773363
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发表时间：
2018-12
影响因子：
3.3
通讯作者：
Chen G
中科院分区：
文献类型：
--
作者：
Gao L;Xu W;Li T;Chen J;Shao A;Yan F;Chen G
自发性脑出血（Spontaneous Intracerebral Hemorrhage，ICH）是世界范围内最严重的脑血管病之一，其发病率和死亡率都很高。然而，仍然缺乏有效的治疗。干细胞治疗在脑出血中显示出良好的神经保护和神经修复作用，是一种很有前途的治疗方法。本文就不同类型干细胞治疗脑出血的疗效、策略、相关机制及安全性问题进行综述。许多研究已经证实了不同类型的干细胞在脑出血中的治疗作用。其作用机制包括组织修复和替代、神经营养、促进神经发生和血管生成、抗凋亡、免疫调节和抗炎等。中枢神经系统（CNS）的微环境也会影响干细胞治疗的效果。ICH治疗的详细治疗策略，如细胞类型、细胞数量、时间窗和给药途径，在不同研究中差异很大，尚未确定。此外，干细胞治疗脑出血的安全性问题不应被忽视。干细胞治疗在脑出血中显示了良好的治疗效果，使其成为一种有前途的治疗方法。但是，安全性还需要仔细评估，在干细胞疗法广泛应用于临床之前，还需要进行更多的临床试验。
Spontaneous intracerebral hemorrhage (ICH) is one type of the most devastating cerebrovascular diseases worldwide, which causes high morbidity and mortality. However, efficient treatment is still lacking. Stem cell therapy has shown good neuroprotective and neurorestorative effect in ICH and is a promising treatment. In this study, our aim was to review the therapeutic effects, strategies, related mechanisms and safety issues of various types of stem cell for ICH treatment. Numerous studies had demonstrated the therapeutic effects of diverse stem cell types in ICH. The potential mechanisms include tissue repair and replacement, neurotrophy, promotion of neurogenesis and angiogenesis, anti-apoptosis, immunoregulation and anti-inflammation and so forth. The microenvironment of the central nervous system (CNS) can also influence the effects of stem cell therapy. The detailed therapeutic strategies for ICH treatment such as cell type, the number of cells, time window, and the routes of medication delivery, varied greatly among different studies and had not been determined. Moreover, the safety issues of stem cell therapy for ICH should not be ignored. Stem cell therapy showed good therapeutic effect in ICH, making it a promising treatment. However, safety should be carefully evaluated, and more clinical trials are required before stem cell therapy can be extensively applied to clinical use.
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慢性中风中的自体间充质干细胞。
影响因子：
1.9
作者：
Bhasin A;Srivastava MV;Kumaran SS;Mohanty S;Bhatia R;Bose S;Gaikwad S;Garg A;Airan B
通讯作者：
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影响因子：
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影响因子：
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