Thyroid cancer incidence in highly observant Jewish neighborhoods in metropolitan New York City.

Thyroid cancer incidence in highly observant Jewish neighborhoods in metropolitan New York City.
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纽约市高度遵守犹太社区的甲状腺癌发病率。

DOI:
10.1089/thy.2011.0091
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发表时间:
2011
期刊:
Thyroid : official journal of the American Thyroid Association
影响因子:
--
通讯作者:
McLaughlin,ColleenC
McLaughlin,ColleenC
中科院分区:
--
文献类型:
--
作者:
Soloway,LauraE;Boscoe,FrancisP;Schymura,MariaJ;Kahn,AmyR;Weinstein,AuraL;Qiao,Baozhen;McLaughlin,ColleenC

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背景:近年来纽约州甲状腺癌发病率迅速上升,特别是在纽约市及其周边大都市区。2007年,白色非西班牙裔美国人中,纽约市大都市区的发病率比该州其他地区高出约40%。在这里,我们探讨在何种程度上生活在一个高比例的高度遵守犹太人的社区可能与此pattern.Methods:我们确定的高度遵守犹太人的基础上使用儿童和东正教犹太教堂的位置与浓度的社区。甲状腺癌风险被建模为生活在这样一个社区的函数,调整年龄,性别和其他因素。该模型重复小(<2 cm)和大(≥2 cm)肿瘤,以评估在驱动的时空patterns.Results的诊断改善的作用:一个中等的关联与甲状腺癌被发现在那些生活在犹太人社区和纽约南部。在那些生活在俄罗斯、白俄罗斯或乌克兰出生的高水平人群社区的人中,发现了较小的关联。在犹太人社区的小肿瘤和大肿瘤中也观察到类似的比率升高,这为该组诊断实践的差异提供了证据。较小的肿瘤在女性和最近诊断的人中更为明显。结论:发现的关联似乎并不是诊断驱动的,而是由于环境,遗传或文化因素在纽约州高度观察的人群中。
Background:Thyroid cancer incidence in New York State has increased rapidly in recent years, particularly in New York City and its surrounding metropolitan area. In 2007 among white non-Hispanics, incidence rates were about 40% higher in the New York City metropolitan area than in the rest of the state. Here we explore the extent to which living in neighborhoods with a high percentage of highly observant Jews may be associated with this pattern.Methods:We identify neighborhoods with concentrations of highly observant Jewish persons based on the use of Yiddish among children and the location of Orthodox synagogues. Thyroid cancer risk is modeled as a function of living in such a neighborhood, adjusting for age, sex, and other factors. The model was repeated for small (<2 cm) and large (≥2 cm) tumors to assess the role of diagnostic improvements in driving the spatial-temporal patterns.Results:A moderate association with thyroid cancer was found among those living in Jewish neighborhoods and downstate New York. A lesser association was found among those who live in neighborhoods of high levels of people born in Russia, Belarus, or Ukraine. Similar elevated rate ratios were seen for small and large tumors in Jewish neighborhoods, providing evidence against differences in diagnostic practices in this group. Smaller tumors were more pronounced among women and persons diagnosed more recently.Conclusions:The associations found do not seem to be diagnostically driven, but rather due to environmental, genetic, or cultural factors in the highly observant population of New York State.
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