Seasonal variation of non-shivering thermogenesis (NST) during mild cold exposure.
Seasonal variation of non-shivering thermogenesis (NST) during mild cold exposure.
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DOI：
10.1186/s40101-015-0051-9
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发表时间：
2015-03-13
影响因子：
3.1
通讯作者：
Watanuki S
中科院分区：
文献类型：
--
作者：
Nishimura T;Motoi M;Egashira Y;Choi D;Aoyagi K;Watanuki S
近年来，人们对非寒战产热（non-发抖thermogenesis， NST）的生理功能进行了研究，一些研究讨论了NST在人体冷适应中的重要性。本研究旨在阐明轻度寒冷暴露导致的NST的个体和季节变化。17名男大学生在夏季和冬季参加了本研究。所使用的气候室经过编程，使环境温度在80分钟内从28°C降至16°C。记录实验过程中被试的生理参数。冬季无寒战时，暴露在寒冷环境中的摄氧量（VO2）的增加明显大于夏季。冬季热中性基线和冷暴露期间呼吸交换比（RER）显著低于夏季同期。此外，ΔVO2与ΔRER呈显著负相关。无寒战状态下VO2的增加表明NST的增加，而RER的降低则与冬季脂肪代谢有关。这些结果表明，NST活性受季节适应的激活，NST的个体变异取决于脂肪代谢的个体变异。
The physiological function of non-shivering thermogenesis (NST) has been investigated in recent years, and some studies have discussed the importance of NST with respect to human cold adaptation. The present study aimed to clarify individual and seasonal variations in NST that occurred as a result of mild cold exposure. Seventeen male university students participated in the present study during summer and winter. The climate chamber used was programmed so that ambient temperature dropped from 28°C to 16°C over an 80-min period. Physiological parameters of test subjects were recorded during the experiments. Increases in oxygen intake (VO2) during cold exposure were significantly greater without shivering in winter than they were in summer. Respiratory exchange ratio (RER) was significantly lower during thermoneutral baseline and cold exposure in winter than it was during the same periods in summer. In addition, there was a significant negative correlation between ΔVO2 and ΔRER. Increase of VO2 without shivering indicated increase of NST, and decrease of RER depends on the metabolization of fat in winter. These results suggested that NST activity was activated by seasonal acclimatization, and individual variation of NST depends on individual variation of fat metabolism.
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影响因子：
7.7
作者：
Saito M;Okamatsu-Ogura Y;Matsushita M;Watanabe K;Yoneshiro T;Nio-Kobayashi J;Iwanaga T;Miyagawa M;Kameya T;Nakada K;Kawai Y;Tsujisaki M
通讯作者：
Tsujisaki M
影响因子：
3.1
作者：
Nishimura T;Motoi M;Niri Y;Hoshi Y;Kondo R;Watanuki S
通讯作者：
Watanuki S
影响因子：
2.9
作者：
van Ooijen, AMJ;Lichtenbelt, WDVM;Westerterp, KR
通讯作者：
Westerterp, KR
解偶联蛋白的群体遗传分析支持 UCP3 在人类抗寒性中的作用。
影响因子：
10.7
作者：
Hancock AM;Clark VJ;Qian Y;Di Rienzo A
通讯作者：
Di Rienzo A
DOI：
10.1111/j.1749-6632.1963.tb17079.x
发表时间：
1963-01-01
期刊：
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES-SERIES
影响因子：
--
作者：
BROZEK, J;ANDERSON, JT;GRANDE, F
通讯作者：
GRANDE, F