High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity.
High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity.
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DOI：
10.2337/db09-0530
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发表时间：
2009-07
期刊：
影响因子：
7.7
通讯作者：
Tsujisaki M
中科院分区：
文献类型：
--
作者：
Saito M;Okamatsu-Ogura Y;Matsushita M;Watanabe K;Yoneshiro T;Nio-Kobayashi J;Iwanaga T;Miyagawa M;Kameya T;Nakada K;Kawai Y;Tsujisaki M
棕色脂肪组织（BAT）在调节能量消耗和肥胖中的重要作用在小型啮齿动物中已经确立，但在人类中一直存在争议。目的是检查代谢活性BAT在健康成年人中的流行率，并阐明寒冷暴露和肥胖的影响。采用正电子发射断层扫描（PET）结合X线计算机断层扫描（CT），对56名23-65岁健康志愿者（男31名，女25名）体内脂肪组织摄取2-[18F]氟-2-脱氧葡萄糖（FDG）进行了测定。当暴露于冷（19°C）2小时时，32名年轻受试者（年龄23-35岁）中的17名和24名老年受试者（年龄38-65岁）中的2名显示出锁骨上和脊柱旁区域的脂肪组织中的大量FDG摄取，而当保持温暖（27°C）时，他们没有显示出可检测的摄取。组织学检查证实在这些区域中存在棕色脂肪细胞。与夏季相比，冬季冷激活FDG摄取量增加（P < 0.001），并且与BMI（P < 0.001）以及脐水平CT图像估计的总脂肪面积（P <0.01）和内脏脂肪面积（P < 0.001）呈负相关。我们的研究结果与传统观点相反，表明代谢活跃的BAT在成年人中的发病率很高，并表明在控制体温和肥胖方面的作用。
The significant roles of brown adipose tissue (BAT) in the regulation of energy expenditure and adiposity are established in small rodents but have been controversial in humans. The objective is to examine the prevalence of metabolically active BAT in healthy adult humans and to clarify the effects of cold exposure and adiposity. In vivo 2-[18F]fluoro-2-deoxyglucose (FDG) uptake into adipose tissue was measured in 56 healthy volunteers (31 male and 25 female subjects) aged 23–65 years by positron emission tomography (PET) combined with X-ray computed tomography (CT). When exposed to cold (19°C) for 2 h, 17 of 32 younger subjects (aged 23–35 years) and 2 of 24 elderly subjects (aged 38–65 years) showed a substantial FDG uptake into adipose tissue of the supraclavicular and paraspinal regions, whereas they showed no detectable uptake when kept warm (27°C). Histological examinations confirmed the presence of brown adipocytes in these regions. The cold-activated FDG uptake was increased in winter compared with summer (P < 0.001) and was inversely related to BMI (P < 0.001) and total (P < 0.01) and visceral (P < 0.001) fat areas estimated from CT image at the umbilical level. Our findings, being against the conventional view, indicate the high incidence of metabolically active BAT in adult humans and suggest a role in the control of body temperature and adiposity.
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影响因子：
3.1
作者：
Garcia, CA;Van Nostrand, D;Majd, M
通讯作者：
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影响因子：
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Parysow, Oscar;Mollerach, Ana M.;Gerbaudo, Victor H.
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DOI：
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发表时间：
2007-07-01
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作者：
Soderlund, Veli;Larsson, Stig A.;Jacobsson, Hans
通讯作者：
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作者：
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通讯作者：
BUKOWIECKI, LJ
DOI：
10.1152/ajpendo.00105.2005
发表时间：
2006-05-01
影响因子：
5.1
作者：
Inokuma, K;Okamatsu-Ogura, Y;Saito, M
通讯作者：
Saito, M