Optogenetics for transcriptional programming and genetic engineering.
Optogenetics for transcriptional programming and genetic engineering.
复制标题
转录编程和基因工程的光遗传学。
DOI：
10.1016/j.tig.2022.05.014
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发表时间：
2022-12
影响因子：
11.4
通讯作者：
Zhou, Yubin
中科院分区：
文献类型：
--
作者：
Lan, Tien-Hung;He, Lian;Huang, Yun;Zhou, Yubin
Optogenetics combines genetics and biophotonics to enable non-invasive control of biological processes with high spatiotemporal precision. When engineered into protein machineries that govern the cellular information flow as depicted in the central dogma, multiple genetically-encoded non-opsin photosensory modules have been harnessed to modulate gene transcription, DNA or RNA modifications, DNA recombination, and genome engineering by utilizing photons emitting in the wide range of 200–1000 nm. We present herein generally-applicable modular strategies for optogenetic engineering, and highlight latest advances in the broad applications of opsin-free optogenetics to program transcriptional outputs and precisely manipulate the mammalian genome, epigenome and epitranscriptome. We also discuss current challenges and future trends in opsin-free optogenetics, which has been rapidly evolving to meet the growing needs in synthetic biology and genetics research.
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DOI：
10.1002/advs.202100424
发表时间：
2021-07
期刊：
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
影响因子：
--
作者：
He L;Huang Z;Huang K;Chen R;Nguyen NT;Wang R;Cai X;Huang Z;Siwko S;Walker JR;Han G;Zhou Y;Jing J
通讯作者：
Jing J
影响因子：
7.7
作者：
Duplus-Bottin H;Spichty M;Triqueneaux G;Place C;Mangeot PE;Ohlmann T;Vittoz F;Yvert G
通讯作者：
Yvert G
影响因子：
7.2
作者：
Engreitz, Jesse;Abudayyeh, Omar;Zhang, Feng
通讯作者：
Zhang, Feng
影响因子：
14.8
作者：
He, Lian;Tan, Peng;Zhou, Yubin
通讯作者：
Zhou, Yubin
DOI：
10.1126/science.aah3404
发表时间：
2016-12-16
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Dagliyan O;Tarnawski M;Chu PH;Shirvanyants D;Schlichting I;Dokholyan NV;Hahn KM
通讯作者：
Hahn KM