The roles of PARP1 in gene control and cell differentiation.
The roles of PARP1 in gene control and cell differentiation.
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DOI：
10.1016/j.gde.2010.06.001
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发表时间：
2010-10
影响因子：
4
通讯作者：
Tulin, Alexei V.
中科院分区：
文献类型：
--
作者：
Ji, Yingbiao;Tulin, Alexei V.
细胞在发育过程中的生长和分化需要许多诱导基因的激活。然而，由DNA和组蛋白组成的真核染色质成为阻碍功能性转录机制的天然屏障。为了突破染色质屏障，真核生物已经进化出使用聚（adp -核糖）聚合酶1 （PARP1）来调节染色质结构并启动导致基因表达控制的步骤的策略。作为染色质中的一种结构蛋白，酶沉默PARP1通过促进染色质的缩聚来抑制转录，从而形成基因转录的屏障。然而，一旦被环境刺激和发育信号激活，PARP1可以修饰自身和其他染色质相关蛋白，从而放松染色质，促进基因转录。在这里，我们讨论PARP1在发育过程中转录控制中的作用。
Cell growth and differentiation during developmental processes require the activation of many inducible genes. However, eukaryotic chromatin, which consists of DNA and histones, becomes a natural barrier impeding access to the functional transcription machinery. To break through the chromatin barrier, eukaryotic organisms have evolved the strategy of using Poly(ADP-ribose) polymerase 1 (PARP1) to modulate chromatin structure and initiate the steps leading to gene expression control. As a structural protein in chromatin, enzymatically silent PARP1 inhibits transcription by contributing to the condensation of chromatin, which creates a barrier against gene transcription. However, once activated by environmental stimuli and developmental signals, PARP1 can modify itself and other chromatin-associated proteins, thereby loosening chromatin to facilitate gene transcription. Here we discuss the roles of PARP1 in transcriptional control during development.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
10.1073/pnas.2237114100
发表时间：
2004-01-06
影响因子：
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通讯作者：
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