Neural crest and cancer: Divergent travelers on similar paths.
Neural crest and cancer: Divergent travelers on similar paths.
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DOI：
10.1016/j.mod.2017.08.002
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发表时间：
2017-12
影响因子：
2.6
通讯作者：
Saxena A
中科院分区：
文献类型：
--
作者：
Gallik KL;Treffy RW;Nacke LM;Ahsan K;Rocha M;Green-Saxena A;Saxena A
神经嵴细胞是多能祖细胞，其动态地解释不同的微环境以作为松散关联的集体迁移显著的距离，并有助于发育中的脊椎动物胚胎中的许多组织。揭示神经嵴迁移的细节有助于对集体细胞迁移的一般理解，包括癌症转移期间发生的迁移。在这里，我们讨论了神经嵴和癌细胞迁移和行为的几个共性和差异。首先，我们专注于一些所需的初始规格和神经嵴细胞的潜力和许多这些途径在癌症进展中的作用的分子途径。我们还描述了上皮细胞向间充质细胞的转化，它在启动神经嵴迁移和癌症转移中起着关键作用。最后，我们评估研究表明，神经嵴和癌症集体迁移过程中细胞-细胞和细胞-环境通信的无数形式，以突出其分子和细胞生物学调控的显着相似性。
Neural crest cells are multipotent progenitors that dynamically interpret diverse microenvironments to migrate significant distances as a loosely associated collective and contribute to many tissues in the developing vertebrate embryo. Uncovering details of neural crest migration has helped to inform a general understanding of collective cell migration, including that which occurs during cancer metastasis. Here, we discuss several commonalities and differences of neural crest and cancer cell migration and behavior. First, we focus on some of the molecular pathways required for the initial specification and potency of neural crest cells and the roles of many of these pathways in cancer progression. We also describe epithelial-to-mesenchymal transition, which plays a critical role in initiating both neural crest migration and cancer metastasis. Finally, we evaluate studies that demonstrate myriad forms of cell-cell and cell-environment communication during neural crest and cancer collective migration to highlight the remarkable similarities in their molecular and cell biological regulation.
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