Measurement of Electrophysiological Signals In Vitro Using High‐Performance Organic Electrochemical Transistors
Measurement of Electrophysiological Signals In Vitro Using High‐Performance Organic Electrochemical Transistors
复制标题
使用高性能有机电化学晶体管测量体外电生理信号
DOI：
10.1002/adfm.202007086
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发表时间：
2020
影响因子：
19
通讯作者：
A. Campbell
中科院分区：
文献类型：
--
作者：
J. Tyrrell;M. Boutelle;A. Campbell
生物环境使用离子进行电荷传输以进行信息传输。有机材料中混合的电子和离子导电性的性质使它们成为将生理信息转换为电子可处理信号的理想候选者。一种被证明在测量这些信息方面非常成功的设备是有机电化学晶体管（OECT）。先前使用OECT进行的电生理测量显示，在低频下信噪比上级电极。随后的开发大大改善了关键的性能参数，如延迟和响应时间。在这里，交叉指型电极OECT在柔性基板上制造，其中一个这样的最先进的设备实现了139 mS的峰值电流，响应时间为138 µs。这些器件被实现为一个阵列，具有适合于微皮层电图应用的互连，并比较了八种架构变体。两个性能最佳的阵列使用预先记录的信号进行完整的电生理频谱。通过频率滤波，可分辨10 µV电压下的kHz频率。这是由一个新的量化的噪声，比较栅极电压输入和漏极电流输出的支持。这些结果表明，高性能OECT可以解析完整的电生理频谱，并表明在多单位活动的高频测量中可以实现上级信噪比。
Biological environments use ions in charge transport for information transmission. The properties of mixed electronic and ionic conductivity in organic materials make them ideal candidates to transduce physiological information into electronically processable signals. A device proven to be highly successful in measuring such information is the organic electrochemical transistor (OECT). Previous electrophysiological measurements performed using OECTs show superior signal‐to‐noise ratios than electrodes at low frequencies. Subsequent development has significantly improved critical performance parameters such as transconductance and response time. Here, interdigitated‐electrode OECTs are fabricated on flexible substrates, with one such state‐of‐the‐art device achieving a peak transconductance of 139 mS with a 138 µs response time. The devices are implemented into an array with interconnects suitable for micro‐electrocorticographic application and eight architecture variations are compared. The two best‐performing arrays are subject to the full electrophysiological spectrum using prerecorded signals. With frequency filtering, kHz‐scale frequencies with 10 µV‐scale voltages are resolved. This is supported by a novel quantification of the noise, which compares the gate voltage input and drain current output. These results demonstrate that high‐performance OECTs can resolve the full electrophysiological spectrum and suggest that superior signal‐to‐noise ratios could be achieved in high frequency measurements of multiunit activity.
影响因子：
12.6
作者：
Hempel, Felix;Law, Jessica Ka-Yan;Ingebrandt, Sven
通讯作者：
Ingebrandt, Sven
DOI：
10.1016/j.msec.2013.07.001
发表时间：
2013-10
期刊：
Materials science & engineering. C, Materials for biological applications
影响因子：
--
作者：
Nemani KV;Moodie KL;Brennick JB;Su A;Gimi B
通讯作者：
Gimi B