Peripheral urocortin delays gastric emptying: role of CRF receptor 2.
Peripheral urocortin delays gastric emptying: role of CRF receptor 2.
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外周尿皮质素延迟胃排空：CRF 受体 2 的作用。
DOI：
10.1152/ajpgi.1999.276.4.g867
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Taché,Y
中科院分区：
文献类型：
--
作者：
Nozu,T;Martinez,V;Rivier,J;Taché,Y
Urocortin, a new mammalian member of the corticotropin-releasing factor (CRF) family has been proposed to be the endogenous ligand for CRF receptor 2 (CRF-R2). We studied the influence of intravenous urocortin on gastric emptying and the role of CRF-R2 in peptide action and postoperative gastric ileus in conscious rats. The intravenous doses of rat CRF and rat urocortin producing 50% inhibition of gastric emptying were 2.5 and 1.1 μg/kg, respectively. At these intravenous doses, CRF and urocortin have their actions fully reversed by the CRF-R1/CRF-R2 antagonist astressin at antagonist/agonist ratios of 5:1 and 67:1, respectively. Astressin (12 μg/kg iv) completely prevented abdominal surgery-induced 54% inhibition of gastric emptying 3 h after surgery while having no effect on basal gastric emptying. The selective nonpeptide CRF-R1 antagonists antalarmin (20 mg/kg ip) and NBI-27914 (400 μg/kg iv) did not influence intravenous CRF-, urocortin- or surgery-induced gastric stasis. These results as well as earlier ones showing that α-helical CRF9—41(a CRF-R2 more selective antagonist) partly prevented postoperative ileus indicate that peripheral CRF-R2 may be primarily involved in intravenous urocortin-, CRF-, and abdominal surgery-induced gastric stasis.
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影响因子：
--
作者：
Chen W. Liaw;D. Grigoriadis;M. Lorang;E. B. D. Souza;Richard A. Maki
通讯作者：
Chen W. Liaw;D. Grigoriadis;M. Lorang;E. B. D. Souza;Richard A. Maki
大鼠肠系膜小动脉中的促肾上腺皮质激素释放激素 (CRH) 受体类似于 (2) 亚型。
影响因子：
5.8
作者：
E. Rohde;J. Furkert;K. Fechner;M. Beyermann;M. Mulvany;R. Richter;C. Denef;M. Bienert;H. Berger
通讯作者：
H. Berger
脂肪酸释放的肽 YY 足以抑制狗的胃排空。
影响因子：
29.4
作者：
T. Pappas;H. Debas;A. M. Chang;I. Taylor
通讯作者：
I. Taylor
DOI：
10.1152/ajpgi.1987.253.4.g582
发表时间：
1987-10
期刊：
The American journal of physiology
影响因子：
--
作者：
C. L. Williams;J. M. Peterson;R. Villar;T. Burks
通讯作者：
C. L. Williams;J. M. Peterson;R. Villar;T. Burks
影响因子：
5
作者：
Wang, Bo;Xiang, Jia;He, Binsheng;Tan, Songwen;Zhou, Wenhu
通讯作者：
Zhou, Wenhu