The diverse and contrasting effects of using human prostate cancer cell lines to study androgen receptor roles in prostate cancer.
The diverse and contrasting effects of using human prostate cancer cell lines to study androgen receptor roles in prostate cancer.
复制标题
使用人类前列腺癌细胞系研究雄激素受体在前列腺癌中的作用的不同和对比效果。
DOI：
10.1038/aja.2008.44
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发表时间：
2009
影响因子：
2.9
通讯作者：
S. Yeh
中科院分区：
文献类型：
--
作者：
Sheng;K. Lai;S. Xia;Hong;Chawnshang Chang;S. Yeh
The androgen receptor (AR) plays an important role in the development and progression of prostate cancer (PCa). Androgen deprivation therapy is initially effective in blocking tumor growth, but it eventually leads to the hormone-refractory state. The detailed mechanisms of the conversion from androgen dependence to androgen independence remain unclear. Several PCa cell lines were established to study the role of AR in PCa, but the results were often inconsistent or contrasting in different cell lines, or in the same cell line grown under different conditions. The cellular and molecular alteration of epithelial cells and their microenvironments are complicated, and it is difficult to use a single cell line to address this important issue and also to study the pathophysiological effects of AR. In this paper, we summarize the different effects of AR on multiple cell lines and show the disadvantages of using a single human PCa cell line to study AR effects on PCa. We also discuss the advantages of widely used epithelium-stroma co-culture systems, xenograft mouse models, and genetically engineered PCa mouse models. The combination of in vitro cell line studies and in vivo mouse models might lead to more credible results and better strategies for the study of AR roles in PCa.
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影响因子：
50.3
作者：
Wang, SY;Gao, J;Wu, H
通讯作者：
Wu, H
影响因子：
--
作者：
Gerald R. Cunha;Elaine T. Alarid;Timothy Turner;A. Donjacour;E. Boutin;B. A. Foster
通讯作者：
Gerald R. Cunha;Elaine T. Alarid;Timothy Turner;A. Donjacour;E. Boutin;B. A. Foster
影响因子：
4.8
作者：
R. Shen;Makoto Sumitomo;Jie Dai;Adam Harris;David Kaminetzky;Min Gao;K. Burnstein;D. M. Nanus-D.-M.-Na
通讯作者：
R. Shen;Makoto Sumitomo;Jie Dai;Adam Harris;David Kaminetzky;Min Gao;K. Burnstein;D. M. Nanus-D.-M.-Na
DOI：
--
发表时间：
1987
期刊：
Progress in clinical and biological research
影响因子：
--
作者：
G. Cunha;A. Donjacour
通讯作者：
G. Cunha;A. Donjacour
DOI：
10.1073/pnas.96.4.1563
发表时间：
1999-02-16
影响因子：
11.1
作者：
Podsypanina, K;Ellenson, LH;Parsons, R
通讯作者：
Parsons, R