Proposal of Quick Diagnostic Criteria for Disseminated Intravascular Coagulation.
Proposal of Quick Diagnostic Criteria for Disseminated Intravascular Coagulation.
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DOI：
10.3390/jcm11041028
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发表时间：
2022-02-16
影响因子：
3.9
通讯作者：
Shimpo H
中科院分区：
文献类型：
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作者：
Wada H;Yamamoto A;Tomida M;Ichikawa Y;Ezaki M;Masuda J;Yoshida M;Fukui S;Moritani I;Inoue H;Shiraki K;Suzuki K;Imai H;Shimaoka M;Shimpo H
背景资料。弥散性血管内凝血(DIC)的诊断标准多种多样，诊断复杂，临界值不同。危重病医生需要简单、快速的DIC诊断标准。材料和方法。检测1293例危重病患者的血小板计数、凝血酶原时间-国际标准化比值(PT-INR)和D-二聚体水平。确定了这些参数的合适临界值，并提出了使用这些生物标志物的快速DIC评分方法。用受试者工作特性(ROC)分析评估快速DIC评分。结果。根据日本厚生劳动省的诊断标准，分别有70名和109名患者被诊断为DIC和Pre-DIC。对弥漫性血管内凝血与非弥漫性血管内凝血的因素差异进行ROC分析，其临界值如下：PT-INR1.2 0，血小板计数12.0×10 10/L，D-二聚体10.0μg/m L。基于上述结果，提出了快速DIC评分系统。所有DIC患者的快速DIC评分均为3、4或5分，85.3%的DIC患者快速DIC评分达到≥3分。所有弥漫性血管内凝血前期患者≥评分均为2分。在ROC分析中，DIC与非DIC的曲线下面积为0.997，DIC+DIC与非DIC的曲线下面积为0.984，DIC和DIC+DIC的临界值分别为3点和2点。死亡患者的快速DIC评分显著高于存活患者。结论。快速DIC评分系统是一种简单实用的工具，可用于DIC和DIC前期的诊断。需要在大规模研究中对快速DIC评分系统进行进一步评估。
Background. The diagnostic criteria for disseminated intravascular coagulation (DIC) vary and are complicated and the cut-off values are different. Simple and quick diagnostic criteria for DIC are required in physicians for critical care. Material and methods. Platelet counts, prothrombin time–international normalized ratio (PT-INR) and D-dimer levels were examined in 1293 critical ill patients. Adequate cut-off values of these parameters were determined and a quick DIC score using these biomarkers was proposed. The quick DIC score was evaluated using a receiver operating characteristic (ROC) analysis. Results. Using the Japanese Ministry of Health, Labor and Welfare diagnostic criteria, 70 and 109 patients were diagnosed with DIC and pre-DIC, respectively. The ROC analysis of factors difference between DIC and non-DIC, revealed the following cut-off values: PT-INR, 1.20; platelet count, 12.0 × 1010/L and D-dimer, 10.0 μg/mL. Based on the above results, the quick DIC score system was proposed. All patients with DIC had a quick DIC score of 3, 4 or 5, and 85.3% of the patients with pre-DIC had a quick DIC score of ≥3 points. All patients with pre-DIC had a score of ≥2 points. In the ROC analysis, the area under the curve was 0.997 for DIC vs. non-DIC, and 0.984 for pre-DIC + DIC vs. non-DIC, and the cut-off value was 3 points for DIC and 2 points for DIC + pre-DIC. The quick DIC scores of non-survivors were significantly higher than those of survivors. Conclusions. The Quick DIC score system is a simple and useful tool that can be used for the diagnosis of DIC and pre-DIC. Further evaluation of the quick DIC score system in a large-scale study is required.
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影响因子：
3.1
作者：
Wada H;Takahashi H;Uchiyama T;Eguchi Y;Okamoto K;Kawasugi K;Madoiwa S;Asakura H;DIC subcommittee of the Japanese Society on Thrombosis and Hemostasis
通讯作者：
DIC subcommittee of the Japanese Society on Thrombosis and Hemostasis
影响因子：
7.1
作者：
Akatsuka M;Masuda Y;Tatsumi H;Sonoda T
通讯作者：
Sonoda T
DOI：
10.1177/1076029620981630
发表时间：
2020-01
期刊：
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
影响因子：
--
作者：
Kuroda H;Masuda Y
通讯作者：
Masuda Y
影响因子：
8.8
作者：
Gando, S;Iba, T;Shimazaki, S
通讯作者：
Shimazaki, S
影响因子：
3.9
作者：
Yamamoto A;Wada H;Ichkawa Y;Tanaka M;Tashiro H;Shiraki K;Shimpo H;Yamashita Y;Mastumoto T;Shimaoka M;Iba T;Suzuki-Inoue K
通讯作者：
Suzuki-Inoue K