Soluble C-Type Lectin-Like Receptor 2 Is a Biomarker for Disseminated Intravascular Coagulation.
Soluble C-Type Lectin-Like Receptor 2 Is a Biomarker for Disseminated Intravascular Coagulation.
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DOI：
10.3390/jcm10132860
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发表时间：
2021-06-28
影响因子：
3.9
通讯作者：
Suzuki-Inoue K
中科院分区：
文献类型：
--
作者：
Yamamoto A;Wada H;Ichkawa Y;Tanaka M;Tashiro H;Shiraki K;Shimpo H;Yamashita Y;Mastumoto T;Shimaoka M;Iba T;Suzuki-Inoue K
弥散性血管内凝血（DIC）是由过度活化凝血引起的，活化血小板也参与发病。因此，血浆可溶性C型凝集素样受体2（sCLEC-2），一个新的血小板活化的标志物，水平可以预期作为一个标记的DIC在危重病人。使用STACIA系统测量血浆sCLEC-2和D-二聚体水平。有DIC基础疾病的患者血浆sCLEC-2和D-二聚体水平显著高于未确诊临床综合征（UCS）患者。DIC及Pre-DIC患者血浆sCLEC-2水平显著高于无DIC及Pre-DIC患者。同样，血浆D-二聚体水平在DIC和Pre-DIC患者中也显著高于那些没有DIC或Pre-DIC的患者。所有患者和DIC评分≤ 4的患者中，死亡患者的血浆sCLEC-2水平显著高于存活患者。所有患者的血浆D-二聚体水平，那些DIC评分≥ 5和那些DIC评分≤ 4，在非幸存者中显著高于幸存者。血浆sCLEC-2有望作为DIC/Pre-DIC的标志物以及危重患者的预后标志物。
Disseminated intravascular coagulation (DIC) is induced by excess activation coagulation, and activated platelets are also involved in pathogenesis. Therefore, plasma levels of soluble C-type lectin-like receptor 2 (sCLEC-2), a new marker for platelet activation, can be expected as a marker of DIC in critically ill patients. Plasma levels of sCLEC-2 and D-dimer were measured using the STACIA system. Plasma sCLEC-2 and D-dimer levels were significantly higher in patients with underlying diseases of DIC than in those with unidentified clinical syndrome (UCS). Plasma sCLEC-2 levels were significantly higher in the patients with DIC and Pre-DIC than in those without DIC or Pre-DIC. Similarly, plasma D-dimer levels were also significantly higher in patients with DIC and Pre-DIC than in those without DIC or Pre-DIC. The plasma sCLEC-2 levels in all patients and those with a DIC score ≤ 4 were significantly higher in non-survivors than survivors. The plasma D-dimer levels in all patients, those with a DIC score ≥ 5 and those with a DIC score ≤ 4, were significantly higher in non-survivors than in survivors. The plasma sCLEC-2 is expected as a marker for DIC/Pre-DIC as well as the prognostic marker in critically ill patients.
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