Hippocampal memory traces are differentially modulated by experience, time, and adult neurogenesis.
Hippocampal memory traces are differentially modulated by experience, time, and adult neurogenesis.
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DOI：
10.1016/j.neuron.2014.05.018
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发表时间：
2014-07-02
期刊：
影响因子：
16.2
通讯作者：
Hen R
中科院分区：
文献类型：
--
作者：
Denny CA;Kheirbek MA;Alba EL;Tanaka KF;Brachman RA;Laughman KB;Tomm NK;Turi GF;Losonczy A;Hen R
记忆痕迹被认为是用来存储记忆的细胞的集合。为了可视化记忆痕迹，我们创建了一个转基因系，可以比较在记忆编码和表达过程中激活的细胞。与暴露在新环境中的小鼠相比，再次暴露在引起恐惧的环境中的小鼠更容易冻结，并且在齿状回（DG）和CA3中有更高比例的再激活细胞。随着时间的推移，这些差异消失了，这与记忆变得一般化的观察结果一致。在恐惧诱导环境编码过程中招募的DG或CA3细胞通过光遗传学沉默阻止了相应记忆的表达。神经发生减少的小鼠表现出较少的情境记忆和较少的CA3再激活，但令人惊讶的是，DG的再激活正常。这些研究表明，不同的记忆痕迹位于DG和CA3中，但记忆的强度与CA3的再激活有关。
Memory traces are believed to be ensembles of cells used to store memories. To visualize memory traces, we created a transgenic line that allows for the comparison between cells activated during encoding and expression of a memory. Mice re-exposed to a fear-inducing context froze more and had a greater percentage of reactivated cells in the dentate gyrus (DG) and CA3 than mice exposed to a novel context. Over time, these differences disappeared, in keeping with the observation that memories become generalized. Optogenetically silencing DG or CA3 cells that were recruited during encoding of a fear-inducing context prevented expression of the corresponding memory. Mice with reduced neurogenesis displayed less contextual memory and less reactivation in CA3 but, surprisingly, normal reactivation in the DG. These studies suggest that distinct memory traces are located in the DG and in CA3 but that the strength of the memory is related to reactivation in CA3.
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影响因子：
56.9
作者：
Santarelli, L;Saxe, M;Hen, R
通讯作者：
Hen, R
DOI：
10.1126/science.1214956
发表时间：
2012-03-09
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Marín-Burgin A;Mongiat LA;Pardi MB;Schinder AF
通讯作者：
Schinder AF
影响因子：
16.2
作者：
Plath, Niels;Ohana, Ora;Kuhl, Dietmar
通讯作者：
Kuhl, Dietmar
影响因子：
16.6
作者：
Niibori, Yosuke;Yu, Tzong-Shiue;Frankland, Paul W.
通讯作者：
Frankland, Paul W.
影响因子：
3.5
作者：
OREILLY, RC;MCCLELLAND, JL
通讯作者：
MCCLELLAND, JL