Epidemiology of Systemic Mycoses in the COVID-19 Pandemic.
Epidemiology of Systemic Mycoses in the COVID-19 Pandemic.
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DOI：
10.3390/jof7070556
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发表时间：
2021-07-13
期刊：
影响因子：
--
通讯作者：
Martínez-Herrera E
中科院分区：
文献类型：
--
作者：
Frías-De-León MG;Pinto-Almazán R;Hernández-Castro R;García-Salazar E;Meza-Meneses P;Rodríguez-Cerdeira C;Arenas R;Conde-Cuevas E;Acosta-Altamirano G;Martínez-Herrera E
COVID-19的病理生理特征（高水平的炎性细胞因子和T细胞减少）促进了真菌定植和感染，这可能会被忽视，因为这两种疾病的症状非常相似。这项工作的目的是研究COVID-19时代系统性真菌病的流行病学现状。在PubMed、Embase、科克伦图书馆和LILACS中对该主题进行了文献检索（2020年1月至2021年2月），无语言限制。人口统计学资料、病原体、危险因素、诊断方法、抗真菌治疗和病死率均被考虑。共发现89篇关于COVID-19与肺孢子虫病、念珠菌病、曲霉病、毛霉菌病、球孢子菌病或组织胞浆菌病合并感染的出版物。一般来说，合并感染发生在40岁以上的男性中，由各种条件引起免疫抑制。在念珠菌病和曲霉病合并感染中发现了几个物种。对于诊断，使用了从微生物到分子的多种方法。大多数患者接受抗真菌药物治疗;然而，死亡率为11- 100%。后者可能是由于临床表现通常仅归因于SARS-CoV-2，从而防止了真菌病的临床怀疑。诊断测试从取样开始也有局限性。因此，在大流行的剩余时间里，必须克服这些诊断限制，以实现更好的患者预后。
The physiopathologic characteristics of COVID-19 (high levels of inflammatory cytokines and T-cell reduction) promote fungal colonization and infection, which can go unnoticed because the symptoms in both diseases are very similar. The objective of this work was to study the current epidemiology of systemic mycosis in COVID-19 times. A literature search on the subject (January 2020–February 2021) was performed in PubMed, Embase, Cochrane Library, and LILACS without language restrictions. Demographic data, etiological agent, risk factors, diagnostic methods, antifungal treatment, and fatality rate were considered. Eighty nine publications were found on co-infection by COVID-19 and pneumocystosis, candidiasis, aspergillosis, mucormycosis, coccidioidomycosis, or histoplasmosis. In general, the co-infections occurred in males over the age of 40 with immunosuppression caused by various conditions. Several species were identified in candidiasis and aspergillosis co-infections. For diagnosis, diverse methods were used, from microbiological to molecular. Most patients received antifungals; however, the fatality rates were 11–100%. The latter may result because the clinical picture is usually attributed exclusively to SARS-CoV-2, preventing a clinical suspicion for mycosis. Diagnostic tests also have limitations beginning with sampling. Therefore, in the remainder of the pandemic, these diagnostic limitations must be overcome to achieve a better patient prognosis.
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DOI：
10.1177/2324709620972244
发表时间：
2020-01
影响因子：
1.2
作者：
Chang CC;Senining R;Kim J;Goyal R
通讯作者：
Goyal R
DOI：
10.3390/pathogens10020157
发表时间：
2021-02-03
期刊：
Pathogens (Basel, Switzerland)
影响因子：
--
作者：
Allaw F;Kara Zahreddine N;Ibrahim A;Tannous J;Taleb H;Bizri AR;Dbaibo G;Kanj SS
通讯作者：
Kanj SS
影响因子：
5.5
作者：
Basso RP;Poester VR;Benelli JL;Stevens DA;Zogbi HE;Vasconcellos ICDS;Pasqualotto AC;Xavier MO
通讯作者：
Xavier MO
2020年4月至7月，印度危害病毒病毒病患者的多药念珠菌感染。
影响因子：
11.8
作者：
Chowdhary A;Tarai B;Singh A;Sharma A
通讯作者：
Sharma A
影响因子：
9.4
作者：
Borman AM;Palmer MD;Fraser M;Patterson Z;Mann C;Oliver D;Linton CJ;Gough M;Brown P;Dzietczyk A;Hedley M;McLachlan S;King J;Johnson EM
通讯作者：
Johnson EM