Opposing effects on cardiac function by calorie restriction in different-aged mice.
Opposing effects on cardiac function by calorie restriction in different-aged mice.
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DOI：
10.1111/acel.12652
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发表时间：
2017-10
期刊：
影响因子：
7.8
通讯作者：
Ding G
中科院分区：
文献类型：
--
作者：
Sheng Y;Lv S;Huang M;Lv Y;Yu J;Liu J;Tang T;Qi H;Di W;Ding G
热量限制（CR）增加了平均和最长寿命，并对年龄相关疾病表现出明显的有益影响。一些研究表明，在中年或老年开始的CR可以提高缺血耐受性并使老化的心脏恢复活力;然而，在年轻时开始的数据并不一致。启动CR的准确时间为老化期间的心脏重塑和功能提供最大受益，目前尚不清楚。因此，在本研究中，研究了在不同年龄的小鼠中启动的相似程度的CR是否可以对心肌保护产生相似的作用。C57 BL/6小鼠在3、12和19个月开始接受热量限制饮食（比随意饮食少40%）3个月。研究发现，CR显著逆转了中年和老年小鼠的衰老表型，包括心脏重塑（心肌细胞肥大和心脏纤维化）、炎症、线粒体损伤、端粒缩短以及衰老相关标志物，但在年轻小鼠中加速。此外，全基因组微阵列表明，AMP活化蛋白激酶（AMPK）-Forkhead box亚组“O”（FOXO）通路可能是不同年龄CR启动的对比调节的主要贡献者;因此，在中年和老年小鼠中观察到自噬增加，但在年轻小鼠中减少。总之，研究结果表明，40% CR的心肌保护应该在中年或老年开始，这可能对实际的营养方案具有重要意义。
Calorie restriction (CR) increases average and maximum lifespan and exhibits an apparent beneficial impact on age‐related diseases. Several studies have shown that CR initiated either in middle or old age could improve ischemic tolerance and rejuvenate the aging heart; however, the data are not uniform when initiated in young. The accurate time to initiate CR providing maximum benefits for cardiac remodeling and function during aging remains unclear. Thus, whether a similar degree of CR initiated in mice of different ages could exert a similar effect on myocardial protection was investigated in this study. C57BL/6 mice were subjected to a calorically restricted diet (40% less than the ad libitum diet) for 3 months initiated in 3, 12, and 19 months. It was found that CR significantly reversed the aging phenotypes of middle‐aged and old mice including cardiac remodeling (cardiomyocyte hypertrophy and cardiac fibrosis), inflammation, mitochondrial damage, telomere shortening, as well as senescence‐associated markers but accelerated in young mice. Furthermore, whole‐genome microarray demonstrated that the AMP‐activated protein kinase (AMPK)–Forkhead box subgroup ‘O’ (FOXO) pathway might be a major contributor to contrasting regulation by CR initiated in different ages; thus, increased autophagy was seen in middle‐aged and old mice but decreased in young mice. Together, the findings demonstrated promising myocardial protection by 40% CR should be initiated in middle or old age that may have vital implications for the practical nutritional regimen.
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影响因子：
7.8
作者：
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