Impaired Succinate Response to a Mixed Meal in Obesity and Type 2 Diabetes Is Normalized After Metabolic Surgery.
Impaired Succinate Response to a Mixed Meal in Obesity and Type 2 Diabetes Is Normalized After Metabolic Surgery.
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DOI：
10.2337/dc20-0460
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发表时间：
2020-10
期刊：
影响因子：
16.2
通讯作者：
Fernández-Veledo S
中科院分区：
文献类型：
--
作者：
Astiarraga B;Martínez L;Ceperuelo-Mallafré V;Llauradó G;Terrón-Puig M;Rodríguez MM;Casajoana A;Pellitero S;Megía A;Vilarrasa N;Vendrell J;Fernández-Veledo S
探讨接受减肥手术的肥胖和2型糖尿病患者循环琥珀酸盐的膳食反应，并检查健康受试者胃肠道葡萄糖感知在琥珀酸盐动力学中的作用。队列I包括45例接受代谢手术的病态肥胖和2型糖尿病患者（BMI 39.4 ± 1.9 kg/m2）。队列II是13例接受胃旁路手术的患者（BMI 39.3 ± 1.4 kg/m2）的确证性队列。队列III包括15例健康受试者（BMI 26.4 ± 0.5 kg/m2）。队列I和II在干预前和1年随访时完成了2小时混合餐耐受试验（MTT），队列II还完成了3小时血脂试验（LT）。队列III进行了3小时口服葡萄糖耐量试验（OGTT）和异甘草酸静脉葡萄糖输注（IIGI）研究。在队列I中，随访时琥珀酸对MTT的反应大于干预前（P < 0.0001）。在队列II中证实了这种反应，手术1年后增加幅度更大（P = 0.009）。相比之下，LT没有引起琥珀酸反应。琥珀酸反应的变化与葡萄糖曲线下面积（r = 0.417，P < 0.0001）和胰岛素曲线下面积（r = 0.204，P = 0.002）的变化相关。在第三组中，顺铂本身刺激了血浆琥珀酸反应（P = 0.0004），但其在OGTT中的反应更大（P = 0.02; OGTT vs IIGI）。肥胖和2型糖尿病患者循环琥珀酸的膳食相关反应在代谢手术后恢复
To explore the meal response of circulating succinate in patients with obesity and type 2 diabetes undergoing bariatric surgery and to examine the role of gastrointestinal glucose sensing in succinate dynamics in healthy subjects. Cohort I comprised 45 patients with morbid obesity and type 2 diabetes (BMI 39.4 ± 1.9 kg/m2) undergoing metabolic surgery. Cohort II was a confirmatory cohort of 13 patients (BMI 39.3 ± 1.4 kg/m2) undergoing gastric bypass surgery. Cohort III comprised 15 healthy subjects (BMI 26.4 ± 0.5 kg/m2). Cohorts I and II completed a 2-h mixed-meal tolerance test (MTT) before the intervention and at 1 year of follow-up, and cohort II also completed a 3-h lipid test (LT). Cohort III underwent a 3-h oral glucose tolerance test (OGTT) and an isoglycemic intravenous glucose infusion (IIGI) study. In cohort I, succinate response to MTT at follow-up was greater than before the intervention (P < 0.0001). This response was confirmed in cohort II with a greater increase after 1 year of surgery (P = 0.009). By contrast, LT did not elicit a succinate response. Changes in succinate response were associated with changes in the area under the curve of glucose (r = 0.417, P < 0.0001) and insulin (r = 0.204, P = 0.002). In cohort III, glycemia, per se, stimulated a plasma succinate response (P = 0.0004), but its response was greater in the OGTT (P = 0.02; OGTT versus IIGI). The meal-related response of circulating succinate in patients with obesity and type 2 diabetes is recovered after metabolic surgery.
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DOI：
10.1152/ajpendo.00571.2005
发表时间：
2006-12-01
影响因子：
5.1
作者：
Muscelli, Elza;Mari, Andrea;Ferrannini, Ele
通讯作者：
Ferrannini, Ele
影响因子：
7.7
作者：
Ho JE;Larson MG;Vasan RS;Ghorbani A;Cheng S;Rhee EP;Florez JC;Clish CB;Gerszten RE;Wang TJ
通讯作者：
Wang TJ
影响因子：
6.5
作者：
Clemente-Postigo, M.;Queipo-Ortuno, M. I.;Tinahones, F. J.
通讯作者：
Tinahones, F. J.
影响因子：
29
作者：
De Vadder, Filipe;Kovatcheva-Datchary, Petia;Mithieux, Gilles
通讯作者：
Mithieux, Gilles
影响因子：
7.7
作者：
McCreath, Kenneth J.;Espada, Sandra;Cervera, Ana M.
通讯作者：
Cervera, Ana M.